{"type":"trials","record":{"id":34059,"source_id":"clinicaltrials-gov","external_id":"NCT04685096","title":"Anti-ageing Efficacy of a Cosmetic Formulation Containing NMN (2%) Versus Placebo","brief_summary":"The study aims at evaluating skin wrinkling, puffiness and fatigue and dark circle appearance on asian and african-american healthy volunteer cohorts receiving a cosmetic formulation containing NMN (2%). The product will be evaluated after 28 and 56 days of twice-daily application in comparison with a reference cosmetic formulation using clinical scoring under dermatological control. Cosmetic acceptability and future use will also be subjectively evaluated by analysis of the subjects answers to an evaluation questionnaire.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Seneque SA","enrollment":89,"countries":["United States","China"],"start_date":"2020-12-12","completion_date":"2021-04-16","last_update_date":"2021-04-23","source_url":"https://clinicaltrials.gov/study/NCT04685096","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:13.198107+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"40 Years to 65 Years","comparator":null,"organization":"Seneque SA","interventions":["Test product creme","Reference creme"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Wrinkles — Change from baseline (day 0) at days 28 and 56 of application","Eye bags — Change from baseline (day 0) at days 28 and 56 of application","Dark circles — Change from baseline (day 0) at days 28 and 56 of application","Relaxed features — Change from baseline (day 0) at days 28 and 56 of application","Subjective evaluation of the product agreeableness and its effects on skin texture, moisture, puffiness, brightness, yo…"],"design_description":null,"source_has_results":false},"controlled_terms":["Wrinkle","Fatigue","Puffiness Around the Eyes","Test product creme","Reference creme"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: nmn.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct04685096","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-12-12 to 2021-04-16","comparator":null,"confidence":"structured-source","population":"FEMALE · 40 Years to 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.593Z","intervention":["Test product creme","Reference creme"],"participants":89,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Wrinkles — Change from baseline (day 0) at days 28 and 56 of application","Eye bags — Change from baseline (day 0) at days 28 and 56 of application","Dark circles — Change from baseline (day 0) at days 28 and 56 of application","Relaxed features — Change from baseline (day 0) at days 28 and 56 of application","Subjective evaluation of the product agreeableness and its effects on skin texture, moisture, puffiness, brightness, yo…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"nad-metabolism","is_published":true,"match_reasons":["Title contains controlled term: nmn.","Abstract contains controlled term: nmn.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"NAD metabolism","slug":"nad-metabolism"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34059","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}