{"type":"trials","record":{"id":34434,"source_id":"clinicaltrials-gov","external_id":"NCT03204604","title":"The Brain Ketone Body Challenge Imaging Study","brief_summary":"The Brain Ketone Body Challenge Imaging Study will measure how the brain uses different fuels. To do this, radioactive compounds will be used during Positron Emission Tomography (PET) imaging. These compounds, called \\[11C\\]Acetoacetate (AcAc) and \\[18F\\] Fludeoxyglucose (FDG), are similar to the sugars and fats the brain already uses for fuel. These compounds safely allow researchers to see how the brain uses sugars and fats during PET scans.","overall_status":"Withdrawn","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Wake Forest University Health Sciences","enrollment":0,"countries":["United States"],"start_date":"2016-08-08","completion_date":"2019-03-01","last_update_date":"2019-03-19","source_url":"https://clinicaltrials.gov/study/NCT03204604","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:17.421904+00:00","last_seen_at":"2026-09-25T06:05:56.331+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years to 85 Years","comparator":null,"organization":"Wake Forest University Health Sciences","interventions":["Challenge A - low calorie Ensure®","Challenge B - Ensure® plus ketone esters (KE)","PET Scan","Cognitive Testing - FCSRT","Story Recall","BVRT","CogState One Card Learning"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Primary Outcome - Brain Ketone Utilization — 2 weeks","Secondary Outcome - Memory Composite Score — 2 weeks"],"design_description":"RANDOMIZED · CROSSOVER · BASIC SCIENCE · TRIPLE","source_has_results":false},"controlled_terms":["Alzheimer Disease","Challenge A - low calorie Ensure®","Challenge B - Ensure® plus ketone esters (KE)","PET Scan","Cognitive Testing - FCSRT","Story Recall","BVRT","CogState One Card Learning"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: ketone body.","quality_checked_at":"2026-09-25T06:05:58.178511+00:00","duplicate_cluster_key":"id:nct03204604","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-08-08 to 2019-03-01","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:56.355Z","intervention":["Challenge A - low calorie Ensure®","Challenge B - Ensure® plus ketone esters (KE)","PET Scan","Cognitive Testing - FCSRT","Story Recall","BVRT","CogState One Card Learning"],"participants":0,"study_design":"RANDOMIZED · CROSSOVER · BASIC SCIENCE · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Primary Outcome - Brain Ketone Utilization — 2 weeks","Secondary Outcome - Memory Composite Score — 2 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"ketogenic-diets","is_published":true,"match_reasons":["Title contains controlled term: ketone body.","Abstract contains controlled term: ketone body.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Ketogenic diets","slug":"ketogenic-diets"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34434","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}