{"type":"trials","record":{"id":34628,"source_id":"clinicaltrials-gov","external_id":"NCT03680677","title":"Frailty Phenotype Assessments to Optimize Treatment Strategies for Older Patients With Hematologic Malignancies","brief_summary":"The purpose of this research study is to determine if frailty assessments can be used to predict how well patients aged 60 years and older will do after chemotherapy, CAR T-cell therapy, or allogeneic stem cell transplant.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Abramson Cancer Center at Penn Medicine","enrollment":20,"countries":["United States"],"start_date":"2018-09-21","completion_date":"2027-11-01","last_update_date":"2026-08-12","source_url":"https://clinicaltrials.gov/study/NCT03680677","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":null,"organization":"Abramson Cancer Center at Penn Medicine","interventions":["Bone Marrow or Peripheral Blood Graft (BMT)","Cancer-directed Therapy or Best Supportive Care","Frailty Assessment"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Non-Relapse Mortality (NRM) in Frail, Pre-Frail, and Non-Frail patients — 1-month","NRM by Intensity of Treatment — 1-month and 6-month"],"design_description":null,"source_has_results":false},"controlled_terms":["Leukemia, Acute","MDS","Bone Marrow or Peripheral Blood Graft (BMT)","Cancer-directed Therapy or Best Supportive Care","Frailty Assessment"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct03680677","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-09-21 to 2027-11-01","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.399Z","intervention":["Bone Marrow or Peripheral Blood Graft (BMT)","Cancer-directed Therapy or Best Supportive Care","Frailty Assessment"],"participants":20,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Non-Relapse Mortality (NRM) in Frail, Pre-Frail, and Non-Frail patients — 1-month","NRM by Intensity of Treatment — 1-month and 6-month"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34628","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}