{"type":"trials","record":{"id":34703,"source_id":"clinicaltrials-gov","external_id":"NCT07579728","title":"CALLY Index, Frailty and SOFA-2 for Mortality Prediction in Geriatric ICU Patients","brief_summary":"This study aims to evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index, Clinical Frailty Scale (CFS), and SOFA-2 score in predicting mortality among geriatric intensive care unit (ICU) patients. The primary outcome is ICU mortality. Secondary outcomes include 28-day mortality, ICU length of stay, duration of mechanical ventilation, need for renal replacement therapy, and vasopressor requirement. The study also investigates whether the combined use of these parameters improves predictive performance compared to conventional scoring systems such as APACHE II.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Istanbul University - Cerrahpasa","enrollment":138,"countries":["Turkey (Türkiye)"],"start_date":"2026-04-30","completion_date":"2026-07-07","last_update_date":"2026-07-09","source_url":"https://clinicaltrials.gov/study/NCT07579728","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"CALLY-FS","age_range":"65 Years","comparator":null,"organization":"Istanbul University - Cerrahpasa","interventions":["observational study"],"registry_source":"ClinicalTrials.gov","outcome_measures":["ICU Mortality — From ICU admission until ICU discharge or death, assessed up to 28 days","28-day Mortality — 28 days","ICU Length of Stay — From ICU admission until ICU discharge or death, assessed up to 28 days","Hospital Length of Stay — From hospital admission until hospital discharge or death, assessed up to 28 days","Duration of Mechanical Ventilation — From initiation of invasive mechanical ventilation until discontinuation, assessed…","Vasopressor Requirement — From ICU admission until ICU discharge or death, assessed up to 28 days","Renal Replacement Therapy Requirement — From ICU admission until ICU discharge or death, assessed up to 28 days"],"design_description":null,"source_has_results":false},"controlled_terms":["Critical Illness","Frailty","Intensive Care Unit (ICU)","observational study"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07579728","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-04-30 to 2026-07-07","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.412Z","intervention":["observational study"],"participants":138,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["ICU Mortality — From ICU admission until ICU discharge or death, assessed up to 28 days","28-day Mortality — 28 days","ICU Length of Stay — From ICU admission until ICU discharge or death, assessed up to 28 days","Hospital Length of Stay — From hospital admission until hospital discharge or death, assessed up to 28 days","Duration of Mechanical Ventilation — From initiation of invasive mechanical ventilation until discontinuation, assessed…","Vasopressor Requirement — From ICU admission until ICU discharge or death, assessed up to 28 days","Renal Replacement Therapy Requirement — From ICU admission until ICU discharge or death, assessed up to 28 days"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34703","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}