{"type":"trials","record":{"id":34705,"source_id":"clinicaltrials-gov","external_id":"NCT07689994","title":"Evaluation of the Effect of a Seaweed Flour- and Leucine-Enriched Food on Metabolic and Inflammatory Status in Older Adults With Probable Sarcopenia or Sarcopenia","brief_summary":"Sarcopenia and probable sarcopenia are associated with loss of muscle strength, functional impairment, frailty, and an increased risk of adverse outcomes in older adults. In short-term interventions, structural or functional changes may be modest, whereas certain serum biomarkers of metabolic-nutritional response may be more sensitive. In this protocol version, serum transthyretin (TTR) has been selected as the primary outcome, without assuming that it represents, by itself, a direct measure of muscle mass or overall clinical efficacy.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Finis Terrae University","enrollment":102,"countries":["Chile"],"start_date":"2026-08-01","completion_date":"2027-03-01","last_update_date":"2026-07-08","source_url":"https://clinicaltrials.gov/study/NCT07689994","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Control chocolate cake; Leucine-enriched chocolate cake","organization":"Finis Terrae University","interventions":["Standard chocolate-flavored cake","Leucine-Enriched Chocolate Cake","Leucine Plus Seaweed Flour-Enriched Chocolate Cake"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change from baseline in fasting serum transthyretin concentration at day 28. — 28 days","Change from baseline in handgrip strength at day 28. — 28 days","Change from baseline in 4-meter gait speed at day 28. — 28 days","Change from baseline in appendicular muscle mass index at day 28. — 28 days","Percentage (%) of prescribed study product serving consumed during the intervention. — 28 days","Number of participants with adequate adherence during the intervention. — 28 days"],"design_description":"RANDOMIZED · PARALLEL · OTHER · TRIPLE","source_has_results":false},"controlled_terms":["Sarcopenia in Elderly","Standard chocolate-flavored cake","Leucine-Enriched Chocolate Cake","Leucine Plus Seaweed Flour-Enriched Chocolate Cake"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct07689994","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-08-01 to 2027-03-01","comparator":"Control chocolate cake; Leucine-enriched chocolate cake","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.400Z","intervention":["Standard chocolate-flavored cake","Leucine-Enriched Chocolate Cake","Leucine Plus Seaweed Flour-Enriched Chocolate Cake"],"participants":102,"study_design":"RANDOMIZED · PARALLEL · OTHER · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change from baseline in fasting serum transthyretin concentration at day 28. — 28 days","Change from baseline in handgrip strength at day 28. — 28 days","Change from baseline in 4-meter gait speed at day 28. — 28 days","Change from baseline in appendicular muscle mass index at day 28. — 28 days","Percentage (%) of prescribed study product serving consumed during the intervention. — 28 days","Number of participants with adequate adherence during the intervention. — 28 days"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34705","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}