{"type":"trials","record":{"id":34815,"source_id":"clinicaltrials-gov","external_id":"NCT07600034","title":"Optimising Exercise to Improve Physical and Cognitive Frailty in Mild Cognitive Impairment","brief_summary":"This investigational research aims to understand the mechanism of delaying the progression of dementia through different types of exercise. Exercise plays a protective role by attenuating the progression of cognitive impairments in mild cognitive impairment (MCI), an early and reversible stage of dementia. However, how different types of exercise induce changes in physical frailty and cognitive function is understudied. The participants will be randomized to receive an exercise intervention program (cycling or strength training) for 12 weeks or a control group. The participants will be asked to perform certain cognitive and physical assessments at the start of the study, at the end of 12 weeks of exercise intervention, and 4 weeks after the end of the intervention. Below is the list of the assessments: * Patient Health Questionnaire-9 (PHQ-9) * World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0-12) * Self-report on sociodemographic characteristics, ethnicity, socioeconomic status, educational level, smoking status, alcohol intake, comorbidities, chronic medications, social activities, history of falls * body height, weight and fat percentage, heart rate, blood pressure, Dual-Energy X-Ray Absorptiometry (DEXA) scan: measurements to evaluate overall physical characteristics * handgrip strength: to evaluate musculoskeletal function * Stroop test: to evaluate information processing speed and executive cognitive control * n-back task: to evaluate working memory and executive function * Timed Up and Go (TUG) test: to measure balance * single-task gait: to measure walking ability * double-task gait: to measure walking stability and attention During Stroop test, n-back task, Timed Up and Go (TUG) test, single-task gait and double-task gait, the participants will be equipped with a mobile functional near-infrared spectroscopy (fNIRS) device over their forehead. This device is used to detect changes in blood flow in the front area of the brain. Their participation will last approximately 18 weeks (2 weeks of familiarization and assessment, 12 weeks of exercise intervention, and 4 weeks of follow-up).","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Universiti Sains Malaysia","enrollment":36,"countries":["Singapore"],"start_date":"2026-07-01","completion_date":"2028-12-31","last_update_date":"2026-05-20","source_url":"https://clinicaltrials.gov/study/NCT07600034","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years to 85 Years","comparator":"Control","organization":"Universiti Sains Malaysia","interventions":["Exercise training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Cerebral blood flow — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after interventi…","Cognitive function — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after interventio…","Physical function — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after intervention…","Physical characteristic — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after interv…","Level of depression — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after interventi…","Level of disability — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after interventi…"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Mild Cognitive Impairment (MCI)","Exercise training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07600034","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-07-01 to 2028-12-31","comparator":"Control","confidence":"structured-source","population":"ALL · 60 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.430Z","intervention":["Exercise training"],"participants":36,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Cerebral blood flow — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after interventi…","Cognitive function — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after interventio…","Physical function — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after intervention…","Physical characteristic — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after interv…","Level of depression — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after interventi…","Level of disability — Before 12-week intervention, immediately after 12-week intervention, and 4 weeks after interventi…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}},{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34815","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}