{"type":"trials","record":{"id":34826,"source_id":"clinicaltrials-gov","external_id":"NCT07366684","title":"Clinical Characteristics, Frailty, and Prognostic Predictors in Patients Aged 75 and Older With Acute Coronary Syndrome","brief_summary":"This study will evaluate clinical characteristics, frailty, and predictors of prognosis in patients aged 75 years and older who are hospitalized with acute coronary syndrome (ACS). The research includes both a retrospective and a prospective cohort. The aim is to determine whether frailty scores, combined with clinical and laboratory parameters available at admission, can improve risk prediction for complications and mortality compared with standard risk scores (TIMI, GRACE, Syntax). The study will also compare outcomes between patients treated with percutaneous coronary intervention (PCI) and those treated conservatively with medications. Patients will be followed during hospitalization and for six months after discharge. The results are expected to contribute to more personalized treatment strategies for elderly patients with ACS.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Clinical Center Niš","enrollment":550,"countries":["Serbia"],"start_date":"2026-05-13","completion_date":"2027-09-01","last_update_date":"2026-05-15","source_url":"https://clinicaltrials.gov/study/NCT07366684","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"75 Years","comparator":null,"organization":"Clinical Center Niš","interventions":["Percutaneous Coronary Intervention (PCI)","Conservative Medical Therapy"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Impact of treatment strategy (PCI vs conservative therapy) on on all-cause mortality and major adverse cardiovascular e…","Impact of treatment strategy (PCI vs conservative therapy) on hemorrhagic complications — Peri-procedurally (within 48…","Number of Participants with ≥1 All-cause Rehospitalization — 6 months after discharge (± 14 days).","Demographic predictors of conservative management — Baseline (Day 1).","Admission hemoglobin as predictor of conservative management — Baseline.","Admission eGFR (CKD-EPI) as predictor of conservative management — Baseline.","Admission hs-Troponin I as predictor of conservative management — Baseline.","Admission CRP as predictor of conservative management — Baseline.","Admission BNP/NT-proBNP as predictor of conservative management — Baseline.","Admission HbA1c as predictor of conservative management — Baseline.","Composite admission laboratory abnormality score as predictor of conservative management — Baseline.","ECG ischemic changes at admission as predictor of conservative management — Baseline","ECG rhythm and arrhythmias at admission as predictor of conservative management — Baseline.","ECG conduction abnormalities at admission as predictor of conservative management — Baseline","Angiographic high-risk anatomy composite as predictor of conservative management — Peri-procedurally (immediately after…","Left Ventricular Ejection Fraction as predictor of conservative management — At admission (transthoracic echo within 72…","E/e' ratio as predictor of conservative management — At admission (transthoracic echo within 72 hours of admission), va…","Pericardial effusion as predictor of conservative management — At admission (transthoracic echo within 72 hours of admi…","Left Atrial Volume Index as predictor of conservative management — At admission (transthoracic echo within 72 hours of…","Wall Motion Score Index as predictor of conservative management — At admission (transthoracic echo within 72 hours of a…"],"design_description":null,"source_has_results":false},"controlled_terms":["ST Elevation (STEMI) Myocardial Infarction","Non ST Elevation Myocardial Infarction (NSTEMI)","Unstable Angina Pectoris","Percutaneous Coronary Intervention (PCI)","Conservative Medical Therapy"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07366684","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-05-13 to 2027-09-01","comparator":null,"confidence":"structured-source","population":"ALL · 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.432Z","intervention":["Percutaneous Coronary Intervention (PCI)","Conservative Medical Therapy"],"participants":550,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Impact of treatment strategy (PCI vs conservative therapy) on on all-cause mortality and major adverse cardiovascular e…","Impact of treatment strategy (PCI vs conservative therapy) on hemorrhagic complications — Peri-procedurally (within 48…","Number of Participants with ≥1 All-cause Rehospitalization — 6 months after discharge (± 14 days).","Demographic predictors of conservative management — Baseline (Day 1).","Admission hemoglobin as predictor of conservative management — Baseline.","Admission eGFR (CKD-EPI) as predictor of conservative management — Baseline.","Admission hs-Troponin I as predictor of conservative management — Baseline.","Admission CRP as predictor of conservative management — Baseline.","Admission BNP/NT-proBNP as predictor of conservative management — Baseline.","Admission HbA1c as predictor of conservative management — Baseline.","Composite admission laboratory abnormality score as predictor of conservative management — Baseline.","ECG ischemic changes at admission as predictor of conservative management — Baseline","ECG rhythm and arrhythmias at admission as predictor of conservative management — Baseline.","ECG conduction abnormalities at admission as predictor of conservative management — Baseline","Angiographic high-risk anatomy composite as predictor of conservative management — Peri-procedurally (immediately after…","Left Ventricular Ejection Fraction as predictor of conservative management — At admission (transthoracic echo within 72…","E/e' ratio as predictor of conservative management — At admission (transthoracic echo within 72 hours of admission), va…","Pericardial effusion as predictor of conservative management — At admission (transthoracic echo within 72 hours of admi…","Left Atrial Volume Index as predictor of conservative management — At admission (transthoracic echo within 72 hours of…","Wall Motion Score Index as predictor of conservative management — At admission (transthoracic echo within 72 hours of a…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34826","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}