{"type":"trials","record":{"id":34840,"source_id":"clinicaltrials-gov","external_id":"NCT03430037","title":"Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women","brief_summary":"This is a pilot study to evaluate whether targeting inflammation will help reduce markers of insulin resistance inflammation, bone resorption and physical dysfunction in elderly women with gait disturbance. Positive results of this study would lead to the development of a larger clinical trial examining the effects of this intervention on age-related dysfunction.","overall_status":"Enrolling By Invitation","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Mayo Clinic","enrollment":40,"countries":["United States"],"start_date":"2018-02-06","completion_date":"2027-11-01","last_update_date":"2026-05-11","source_url":"https://clinicaltrials.gov/study/NCT03430037","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Enrolling By Invitation. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"FEMALE","acronym":"AFFIRM","age_range":"70 Years","comparator":"Placebo","organization":"Mayo Clinic","interventions":["Fisetin","Placebo oral capsule"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Improved 6 minute walk — One Month"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Frail Elderly Syndrome","Fisetin","Placebo oral capsule"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct03430037","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-02-06 to 2027-11-01","comparator":"Placebo","confidence":"structured-source","population":"FEMALE · 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.435Z","intervention":["Fisetin","Placebo oral capsule"],"participants":40,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Improved 6 minute walk — One Month"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34840","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}