{"type":"trials","record":{"id":34845,"source_id":"clinicaltrials-gov","external_id":"NCT06844318","title":"Impact of IBD Activity on Frailty in Patients Over 60 Years","brief_summary":"The goal of this observational, multicenter, descriptive, prospective, and longitudinal study is to evaluate the impact of IBD activity on frailty in a prospective and longitudinal cohort of patients with IBD, and also to assess the impact of frailty on the risk of hospitalization and mortality in patients with IBD aged ≥60 years. The main questions it aims to answer are: 1. Can frailty and consequently the risk of complications (adverse events, hospitalization, and mortality) be reversed through proactive treatment in frail patients with active inflammatory bowel disease? 2. Which frailty index is the most effective for predicting the risk of complications in patients with active inflammatory bowel disease? At inclusion, clinical frailty indices will be calculated. Additionally, clinical variables related to IBD and comorbidities will be recorded. During follow ups visits frailty, comorbidities, IBD activity, changes in medical treatment for IBD, adverse effects, hospitalizations, and mortality will be reassessed.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa","enrollment":153,"countries":["Spain"],"start_date":"2025-04-14","completion_date":"2027-05-01","last_update_date":"2026-05-07","source_url":"https://clinicaltrials.gov/study/NCT06844318","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"FRAGIL","age_range":"60 Years","comparator":null,"organization":"Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["To evaluate the impact of inflamatory bowel disease (IBD) activity on frailty in a prospective and longitudinal cohort…","To assess the impact of frailty on the risk of hospitalization and mortality in patients with IBD aged ≥60 years. — 12…"],"design_description":null,"source_has_results":false},"controlled_terms":["IBD"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06844318","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-04-14 to 2027-05-01","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.435Z","intervention":[],"participants":153,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["To evaluate the impact of inflamatory bowel disease (IBD) activity on frailty in a prospective and longitudinal cohort…","To assess the impact of frailty on the risk of hospitalization and mortality in patients with IBD aged ≥60 years. — 12…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty, frailty index.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34845","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}