{"type":"trials","record":{"id":34849,"source_id":"clinicaltrials-gov","external_id":"NCT03880422","title":"Nutrition and Exercise Interventions for Androgen Deprivation Therapy-Induced Obese Frailty in Elderly and Non-Elderly Survivors of Advanced Prostate Cancer","brief_summary":"This trial studies how well nutrition and exercise interventions work in reducing androgen deprivation therapy-induced obese frailty in prostate cancer survivors. Individualized nutrition and exercise advice for prostate cancer patients on androgen deprivation therapy may help to reduce obese frailty and change the levels of myokines in blood.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Roswell Park Cancer Institute","enrollment":50,"countries":["United States"],"start_date":"2019-05-02","completion_date":"2029-05-02","last_update_date":"2026-05-07","source_url":"https://clinicaltrials.gov/study/NCT03880422","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"MALE","acronym":null,"age_range":"18 Years","comparator":null,"organization":"Roswell Park Cancer Institute","interventions":["Dietary Intervention","Educational Intervention","Exercise Intervention","Quality-of-Life Assessment","Survey Administration"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Changes in body composition — Baseline up to 6 months","Changes in muscle strength — Baseline up to 6 months","Changes in functional capacity muscle strength — Baseline up to 6 months","Change in body composition — Baseline up to 6 months","myokines concentration — Baseline up to 6 months","cytokines concentration — Baseline up to 6 months","Health related quality of life Short Form — Up to 6 months","Changes in dietary intake — Baseline up to 6 months","Changes in physical activity — Baseline up to 6 months","Change in fatigue — Baseline up to 6 months","Change in Respiratory Muscle Strength — Baseline up to 6 months"],"design_description":"NA · SINGLE GROUP · SUPPORTIVE CARE · NONE","source_has_results":false},"controlled_terms":["Cancer Survivor","Obesity","Overweight","Prostate Adenocarcinoma","Stage A Prostate Cancer","Stage B Prostate Cancer","Stage C Prostate Cancer","Stage D Prostate Cancer","Stage I Prostate Cancer","Stage II Prostate Cancer","Stage IIA Prostate Cancer","Stage IIB Prostate Cancer","Stage IIC Prostate Cancer","Stage III Prostate Cancer","Stage IIIA Prostate Cancer","Stage IIIB Prostate Cancer","Stage IIIC Prostate Cancer","Stage IV Prostate Cancer","Stage IVA Prostate Cancer","Stage IVB Prostate Cancer","Dietary Intervention","Educational Intervention","Exercise Intervention","Quality-of-Life Assessment","Survey Administration"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct03880422","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-05-02 to 2029-05-02","comparator":null,"confidence":"structured-source","population":"MALE · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.436Z","intervention":["Dietary Intervention","Educational Intervention","Exercise Intervention","Quality-of-Life Assessment","Survey Administration"],"participants":50,"study_design":"NA · SINGLE GROUP · SUPPORTIVE CARE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Changes in body composition — Baseline up to 6 months","Changes in muscle strength — Baseline up to 6 months","Changes in functional capacity muscle strength — Baseline up to 6 months","Change in body composition — Baseline up to 6 months","myokines concentration — Baseline up to 6 months","cytokines concentration — Baseline up to 6 months","Health related quality of life Short Form — Up to 6 months","Changes in dietary intake — Baseline up to 6 months","Changes in physical activity — Baseline up to 6 months","Change in fatigue — Baseline up to 6 months","Change in Respiratory Muscle Strength — Baseline up to 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}},{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34849","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}