{"type":"trials","record":{"id":34861,"source_id":"clinicaltrials-gov","external_id":"NCT07335978","title":"Chair Exercise and Intergenerational Activities in Older Adults With Physio-Cognitive Decline Syndrome","brief_summary":"The goal of this clinical trial is to investigate the effects of chair exercise followed by intergenerational activity in frailty syndrome and changes in serum mBDN levels among older adults with Physio-Cognitive Decline Syndrome (PCDS), as a novel approach integrating physical and social intervention with biomolecular assessments In older adults with PCDS 1. Does A 16-week program of chair exercise followed by intergenerational activity improve handgrip strength (HGS), gait speed, MoCA-Ina scores, and health-related quality of life? 2. Does a 16-week program of chair exercise followed by an intergenerational activity increase serum mBDNF level? 3. Are serum mBDNF levels associated with MoCA-Ina scores, gait speed, and handgrip strength? Intervention Group Participants will undergo a 12-week structured chair exercise program, conducted with a trained exercise instructor and supervised by a physician for vital sign monitoring during each session. The frequency of sessions will increase progressively: * Weeks 1-2: once weekly * Weeks 3-6: twice weekly * Week 7-12: three times weekly Additional activities include (intervention and control group): * Weeks 1 and 11: teleconference session on nutrition and physical exercise supported by electronic flyers (e-flyers). * Weeks 3, 5, 7, 11, and 13: distribution of e-flyers on elderly nutrition and the muscle-brain axis. Additional Activity (intervention group) \\- Weeks 13-16: intergenerational activities at an orphanage with children aged \\>5 years Assessments (intervention and control group): * Week 1: serum mBDNF and HbA1c measurement * Week 12 and 16: physical assessments (body weight, height, handgrip strength, gait speed, MoCA-Ina, and IADL) and serum mBDNF measurement. Control Group: The participant will receive general health education on performing physical exercise 1-3 times per week throughout week 1-16","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Atma Jaya Catholic University of Indonesia","enrollment":100,"countries":["Indonesia"],"start_date":"2025-09-24","completion_date":"2026-03-16","last_update_date":"2026-05-04","source_url":"https://clinicaltrials.gov/study/NCT07335978","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"PCDS","age_range":"60 Years to 75 Years","comparator":"Control Arm","organization":"Atma Jaya Catholic University of Indonesia","interventions":["Intervention 1"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Frailty Syndrome Status — From enrollment to the end of treatment at 12 weeks","serum mature brain-derived neurotrophic factor (mBDNF) — from baseline to week 16","Hand grip strength — from baseline to week 16","Gait Speed Test — baseline to week 16","Cognitive Function — from baseline to week 16","health-related quality of life (SF-12 questionnaire) — from baseline to week 16","serum mBDNF levels — baseline to week 16"],"design_description":"RANDOMIZED · CROSSOVER · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Cognitive Frailty","Intervention 1"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07335978","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-09-24 to 2026-03-16","comparator":"Control Arm","confidence":"structured-source","population":"ALL · 60 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.438Z","intervention":["Intervention 1"],"participants":100,"study_design":"RANDOMIZED · CROSSOVER · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Frailty Syndrome Status — From enrollment to the end of treatment at 12 weeks","serum mature brain-derived neurotrophic factor (mBDNF) — from baseline to week 16","Hand grip strength — from baseline to week 16","Gait Speed Test — baseline to week 16","Cognitive Function — from baseline to week 16","health-related quality of life (SF-12 questionnaire) — from baseline to week 16","serum mBDNF levels — baseline to week 16"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34861","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}