{"type":"trials","record":{"id":34871,"source_id":"clinicaltrials-gov","external_id":"NCT06866678","title":"Frailty Score and Postoperative Morbidity in Colorectal Cancer Surgery","brief_summary":"This prospective observational study aims to evaluate the independent predictive value of the Edmonton Frailty Index (EFI) in estimating postoperative morbidity among older patients undergoing elective colorectal cancer surgery. Frailty, characterized by a decline in physiological reserves and increased vulnerability to stressors, has been recognized as a stronger predictor of adverse postoperative outcomes than chronological age alone. While the relationship between frailty and surgical outcomes has been extensively investigated in general surgical populations, data specifically focusing on patients with colorectal cancer remain limited. In this study, patients aged 65 years and older scheduled for elective colorectal cancer surgery will undergo preoperative frailty assessment using the validated Edmonton Frailty Index (EFI). Postoperative complications, length of intensive care unit (ICU) stay, total hospital stay, and 30-day adverse outcomes, including mortality, myocardial infarction, pulmonary embolism, sepsis, and the need for reoperation, will be recorded and analyzed. The primary objective is to determine whether frailty, as measured by the Edmonton Frailty Index, serves as an independent predictor of postoperative morbidity in this specific patient population. Secondary objectives include exploring associations between frailty and intraoperative variables such as blood loss, fluid administration, and vasopressor requirements. By addressing this gap, the study aims to contribute to the growing body of evidence supporting the routine incorporation of frailty assessment into preoperative risk stratification protocols for older patients with colorectal cancer. The ultimate goal is to enhance perioperative risk assessment, optimize perioperative care, and improve patient outcomes.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital","enrollment":200,"countries":["Turkey (Türkiye)"],"start_date":"2025-03-02","completion_date":"2025-11-01","last_update_date":"2026-04-30","source_url":"https://clinicaltrials.gov/study/NCT06866678","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":null,"organization":"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital","interventions":["Observational Data Collection"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Postoperative Complication Rate Postoperative Complication Rate (Clavien-Dindo ≥ Grade II) — 30 days after surgery","Postoperative Mortality — 30 days after surgery","Length of Hospital Stay — From surgery to hospital discharge (up to 30 days)","ICU Admission and Length of Stay — From surgery to hospital discharge (up to 30 days)","Surgical Site Infection — 30 days after surgery","Unplanned Reoperation — 30 days after surgery","Unplanned Readmission — 30 days after discharge","Postoperative Delirium — During hospital stay (up to 14 days)"],"design_description":null,"source_has_results":false},"controlled_terms":["Postoperative Complications","Colorectal Cancer","Frailty","Observational Data Collection"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06866678","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-03-02 to 2025-11-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.439Z","intervention":["Observational Data Collection"],"participants":200,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Postoperative Complication Rate Postoperative Complication Rate (Clavien-Dindo ≥ Grade II) — 30 days after surgery","Postoperative Mortality — 30 days after surgery","Length of Hospital Stay — From surgery to hospital discharge (up to 30 days)","ICU Admission and Length of Stay — From surgery to hospital discharge (up to 30 days)","Surgical Site Infection — 30 days after surgery","Unplanned Reoperation — 30 days after surgery","Unplanned Readmission — 30 days after discharge","Postoperative Delirium — During hospital stay (up to 14 days)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty, frailty index.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34871","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}