{"type":"trials","record":{"id":34901,"source_id":"clinicaltrials-gov","external_id":"NCT07477561","title":"Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-ICOPE for Healthy Ageing in Singapore","brief_summary":"The goal of this intervention study is to screen and identify frailty and decline in intrinsic capacity (physical and mental capacities) in community-dwelling older adults in Singapore, and to evaluate whether early identification and targeted interventions can improve health outcomes and support healthy ageing. The main questions it aims to answer are: * Can combined frailty and intrinsic capacity screening with targeted interventions prevent or reduce functional decline in older adults, as measured by changes in life space mobility? * Will at least 80% of screened older adults adhere to recommended care pathways and interventions? * Can this screening and intervention programme demonstrate sustainability through continued community participation and recruitment of new partner organizations beyond the initial implementation phase? The investigators will compare an intervention group (receiving immediate assessment and clinical referrals based on identified needs) to a wait-list control group (receiving the same interventions 12 months later) to see if early intervention leads to better health outcomes and quality of life. Participants will: * Attend 4 study visits over 2 years (at 6-monthly intervals in the first year, with final assessment at end of year 2), each lasting up to 2 hours. * Undergo comprehensive screening assessments including mobility, cognition, mental health, hearing, vision, and nutritional status. * Receive 2 follow-up phone calls at 3-month and 9-month intervals to monitor progress. * If in the intervention group: receive personalized referrals for further care (which may include comprehensive geriatric assessment, primary care reviews, rehabilitation, or dietitian consultations) and guidance on using a mobile health monitoring application. * If in the wait-list control group: receive the same interventions after their 3rd study visit (12 months later).","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Sengkang General Hospital","enrollment":600,"countries":["Singapore"],"start_date":"2023-07-17","completion_date":"2028-01-15","last_update_date":"2026-04-17","source_url":"https://clinicaltrials.gov/study/NCT07477561","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"INFINITY-ICOPE","age_range":"60 Years","comparator":"Intervention with further assessment and clinical referrals based on needs identified","organization":"Sengkang General Hospital","interventions":["INFINITY-ICOPE programme"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Life space mobility — From enrollment to the end of intervention at 12 months.","Community implementation outcomes of INFINITY-ICOPE programme — Fidelity: Assessed continuously throughout the 24-month…","Adherence to automated frailty screening and remote intrinsic capacity monitoring — Assessed at baseline, 6, 12, and 24…","Prevention of frailty progression and preservation of intrinsic capacity — Assessed at baseline, 6, 12, and 24 months.","Health-related quality of life improvement — Assessed at baseline, 6, 12, and 24 months.","Healthcare service utilization — Assessed at baseline, 6, 12, and 24 months.","Association between oral frailty and physical frailty for risk stratification — Assessed at baseline, 6, 12, and 24 mon…"],"design_description":"NON RANDOMIZED · CROSSOVER · HEALTH SERVICES RESEARCH · NONE","source_has_results":false},"controlled_terms":["Frailty in Older Adults","Intrinsic Capacity","Age-related Functional Decline","Healthy Ageing","INFINITY-ICOPE programme"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07477561","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-07-17 to 2028-01-15","comparator":"Intervention with further assessment and clinical referrals based on needs identified","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.444Z","intervention":["INFINITY-ICOPE programme"],"participants":600,"study_design":"NON RANDOMIZED · CROSSOVER · HEALTH SERVICES RESEARCH · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Life space mobility — From enrollment to the end of intervention at 12 months.","Community implementation outcomes of INFINITY-ICOPE programme — Fidelity: Assessed continuously throughout the 24-month…","Adherence to automated frailty screening and remote intrinsic capacity monitoring — Assessed at baseline, 6, 12, and 24…","Prevention of frailty progression and preservation of intrinsic capacity — Assessed at baseline, 6, 12, and 24 months.","Health-related quality of life improvement — Assessed at baseline, 6, 12, and 24 months.","Healthcare service utilization — Assessed at baseline, 6, 12, and 24 months.","Association between oral frailty and physical frailty for risk stratification — Assessed at baseline, 6, 12, and 24 mon…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: ageing, frailty.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34901","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}