{"type":"trials","record":{"id":34912,"source_id":"clinicaltrials-gov","external_id":"NCT07522359","title":"A Short-Bout Combined Aerobic and Resistance Exercise Program in Older Adults With Diabetes and Probable Sarcopenia","brief_summary":"Older adults with diabetes are at high risk of developing sarcopenia. A preclinical stage, known as \"probable sarcopenia\" (defined by low muscle strength), represents a critical window for early intervention. Physical activity is an effective strategy, but many patients struggle to maintain regular exercise. This parallel-group randomized controlled trial aims to evaluate the effectiveness of a 12-week home-based, short-bout combined aerobic and resistance exercise program on physical activity level and muscle strength among older adults with diabetes and probable sarcopenia.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Sun Yat-sen University","enrollment":73,"countries":[],"start_date":"2026-04-01","completion_date":"2027-01-01","last_update_date":"2026-04-13","source_url":"https://clinicaltrials.gov/study/NCT07522359","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Usual Community Diabetes Care","organization":"Sun Yat-sen University","interventions":["Short-Bout Combined Exercise Program"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Physical Activity Level — Baseline, 12 weeks, and 24 weeks","Change in Muscle Strength — Baseline, 12 weeks, and 24 weeks","Change in Appendicular Skeletal Muscle Mass Index — Baseline, 12 weeks, and 24 weeks","Change in Skeletal Muscle Mass — Baseline, 12 weeks, and 24 weeks","Change in Physical Performance — Baseline, 12 weeks, and 24 weeks","Reversal rate of probable sarcopenia — Baseline, 12 weeks, and 24 weeks","Change in Glycated Hemoglobin — Baseline, 12 weeks, and 24 weeks","Change in Fasting Plasma Glucose — Baseline, 12 weeks, and 24 weeks","Change in Sarcopenia Awareness — Baseline, 12 weeks, and 24 weeks","Change in Sarcopenia risk — Baseline, 12 weeks, and 24 weeks","Change in Nutritional Status — Baseline, 12 weeks, and 24 weeks","Change in Frailty Level — Baseline, 12 weeks, and 24 weeks","Change in Fall risk — Baseline, at 12 weeks post-intervention, and at 24 weeks post-intervention","Change in Depressive Symptoms — Baseline, 12 weeks, and 24 weeks","Number of Adverse Events — Throughout the study (Baseline to 24 weeks)","Cost-Utility Analysis Indicators — Baseline, 24 weeks","Process Evaluation Indicators — Throughout the study (Baseline to 24 weeks)","Change in Total Body Water — Baseline, 12 weeks, and 24 weeks","Change in Inorganic Salt Mass — Baseline, 12 weeks, and 24 weeks","Change in Fat Mass — Baseline, 12 weeks, and 24 weeks"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","source_has_results":false},"controlled_terms":["Sarcopenia","Diabetes","Short-Bout Combined Exercise Program"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07522359","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-04-01 to 2027-01-01","comparator":"Usual Community Diabetes Care","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.789Z","intervention":["Short-Bout Combined Exercise Program"],"participants":73,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Physical Activity Level — Baseline, 12 weeks, and 24 weeks","Change in Muscle Strength — Baseline, 12 weeks, and 24 weeks","Change in Appendicular Skeletal Muscle Mass Index — Baseline, 12 weeks, and 24 weeks","Change in Skeletal Muscle Mass — Baseline, 12 weeks, and 24 weeks","Change in Physical Performance — Baseline, 12 weeks, and 24 weeks","Reversal rate of probable sarcopenia — Baseline, 12 weeks, and 24 weeks","Change in Glycated Hemoglobin — Baseline, 12 weeks, and 24 weeks","Change in Fasting Plasma Glucose — Baseline, 12 weeks, and 24 weeks","Change in Sarcopenia Awareness — Baseline, 12 weeks, and 24 weeks","Change in Sarcopenia risk — Baseline, 12 weeks, and 24 weeks","Change in Nutritional Status — Baseline, 12 weeks, and 24 weeks","Change in Frailty Level — Baseline, 12 weeks, and 24 weeks","Change in Fall risk — Baseline, at 12 weeks post-intervention, and at 24 weeks post-intervention","Change in Depressive Symptoms — Baseline, 12 weeks, and 24 weeks","Number of Adverse Events — Throughout the study (Baseline to 24 weeks)","Cost-Utility Analysis Indicators — Baseline, 24 weeks","Process Evaluation Indicators — Throughout the study (Baseline to 24 weeks)","Change in Total Body Water — Baseline, 12 weeks, and 24 weeks","Change in Inorganic Salt Mass — Baseline, 12 weeks, and 24 weeks","Change in Fat Mass — Baseline, 12 weeks, and 24 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise, physical activity.","Source terminology contains: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}},{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34912","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}