{"type":"trials","record":{"id":34968,"source_id":"clinicaltrials-gov","external_id":"NCT07310667","title":"Assessing the Relationship Between Frailty and Skeletal Muscle Thickness in Critically Ill Patients","brief_summary":"Assessment of muscle mass in critically ill patients is critical for both improving clinical outcomes and monitoring the effectiveness of nutritional interventions. Loss of muscle mass is associated with mortality and morbidity in the elderly, including organ transplantation, trauma, and sepsis. Previous studies have assessed muscle mass using computed tomography. The use of computed tomography is costly, carries radiation risks, and requires the patient to be transported to a CT scanner. In contrast, ultrasonography is a noninvasive, rapid, and bedside method without radiation exposure. In particular, anterior thigh muscle thickness (ATMT) stands out as a reliable biomarker in the assessment of muscle mass. ATMT measurement includes the assessment of the combined depth of the vastus intermedius and rectus femoris muscles in the anterior thigh. There is no study in the literature examining the effects of anterior thigh muscle thickness measured by ultrasonography on malnutrition and frailty in intensive care patients. In this study, we aimed to investigate the effects of anterior thigh muscle thickness on frailty, malnutrition and length of stay in intensive care patients.","overall_status":"Enrolling By Invitation","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Ankara Training and Research Hospital","enrollment":80,"countries":["Turkey (Türkiye)"],"start_date":"2025-05-02","completion_date":"2027-05-31","last_update_date":"2026-03-19","source_url":"https://clinicaltrials.gov/study/NCT07310667","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Enrolling By Invitation. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"Ankara Training and Research Hospital","interventions":["Muscle ultrasound"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Front Thigh Muscle Measurement — Ultrasound assessments will be performed within 24 hours of intensive care unit (ICU)…","Frailty Assessment — Frailty will be ascertained at ICU admission by interviewing family/caregivers about the patient's…","Nutritional Status Assessment — Will be ascertained at ICU admission by interviewing with family/caregivers","Critical Care Scoring System: APACHE II — During the first 24 hours of ICU admission"],"design_description":null,"source_has_results":false},"controlled_terms":["Fraility","Nutrition Assessment","Ultrasound Evaluation","Critical Illness","Muscle ultrasound"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07310667","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-05-02 to 2027-05-31","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.454Z","intervention":["Muscle ultrasound"],"participants":80,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Front Thigh Muscle Measurement — Ultrasound assessments will be performed within 24 hours of intensive care unit (ICU)…","Frailty Assessment — Frailty will be ascertained at ICU admission by interviewing family/caregivers about the patient's…","Nutritional Status Assessment — Will be ascertained at ICU admission by interviewing with family/caregivers","Critical Care Scoring System: APACHE II — During the first 24 hours of ICU admission"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34968","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}