{"type":"trials","record":{"id":34984,"source_id":"clinicaltrials-gov","external_id":"NCT07448909","title":"Cognitive-Frailty Gait Biomechanics for Early Dementia Detection","brief_summary":"The purpose of this study is to better understand how physical characteristics, walking patterns, and a blood-based brain health marker differ between older adults with dementia and healthy older adults. Dementia is often associated with changes in physical health and movement, but these changes are not fully understood. This study asks whether people with dementia show differences in body composition, walking ability, and levels of brain-derived neurotrophic factor (BDNF), a protein involved in brain function, compared with individuals without dementia. To answer this question, participants will complete a single assessment session that includes basic physical measurements, an assessment of walking while moving at a comfortable pace, and a small blood sample collection. The information collected will be used to compare the two groups and explore possible relationships between physical function, walking patterns, and BDNF levels.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Universiti Sains Malaysia","enrollment":60,"countries":["Malaysia"],"start_date":"2026-02-01","completion_date":"2029-12-31","last_update_date":"2026-03-04","source_url":"https://clinicaltrials.gov/study/NCT07448909","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"gait dementia","age_range":"50 Years","comparator":null,"organization":"Universiti Sains Malaysia","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Gait speed during normal walking — At baseline (single assessment)","Stride length during normal walking — At baseline","Cadence during normal walking — At baseline (single assessment)","Cognitive function assessed by the Montreal Cognitive Assessment (MoCA) — At baseline (single assessment)","Cognitive function assessed by the Mini-Mental State Examination (MMSE) — At baseline (single assessment)","Handgrip strength — At baseline","Serum brain-derived neurotrophic factor (BDNF) concentration — At baseline","Functional mobility assessed by the Timed Up and Go test — At baseline (single assessment)"],"design_description":null,"source_has_results":false},"controlled_terms":["Mild Cognitive Impairment (MCI)"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07448909","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-02-01 to 2029-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.457Z","intervention":[],"participants":60,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Gait speed during normal walking — At baseline (single assessment)","Stride length during normal walking — At baseline","Cadence during normal walking — At baseline (single assessment)","Cognitive function assessed by the Montreal Cognitive Assessment (MoCA) — At baseline (single assessment)","Cognitive function assessed by the Mini-Mental State Examination (MMSE) — At baseline (single assessment)","Handgrip strength — At baseline","Serum brain-derived neurotrophic factor (BDNF) concentration — At baseline","Functional mobility assessed by the Timed Up and Go test — At baseline (single assessment)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34984","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}