{"type":"trials","record":{"id":34985,"source_id":"clinicaltrials-gov","external_id":"NCT06604104","title":"Visual Frailty in Ageing","brief_summary":"The goal of this observational study is to define visual frailty and refine monitoring for an ageing population. It involves piloting a visual frailty assessment tool in a cohort of patients aged 60 and above with a known diagnosis of Age-related Macular Degeneration (AMD) in Princess Alexandra Eye Pavilion (PAEP), Anne Rowling Clinic which is hosting the NHS Low Visual Aid Clinic, or any other NHS Lothian facility treating patients with Age-related Macular Degeneration (AMD). The main questions it aims to answer are: * What is visual frailty and how can it be assessed or predicted in the global ageing population using visual acuity, reading performance, functional status, mental health and systemic co-morbidities? * What is the relationship between visual acuity, reading performance, ocular diagnosis, co-morbidities, mental health, and functional status? Participants will have the following data collected from them from either Princess Alexandra Eye Pavilion, Anne Rowling Clinic which is hosting the NHS Low Visual Aid Clinic, or any other NHS Lothian facility treating patients with Age-related Macular Degeneration (AMD): * Visual acuity (both distance and near) * Reading performance * Functional status * Mental health * Co-morbidities Data will also be collected remotely (by phone call) from both the participants and their carers/relatives about their perceptions of visual frailty. Expert opinion will be sought from optometrists and ophthalmologists about the concept of visual frailty using an online survey.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Edinburgh","enrollment":20,"countries":["United Kingdom"],"start_date":"2025-04-09","completion_date":"2027-02-01","last_update_date":"2026-03-04","source_url":"https://clinicaltrials.gov/study/NCT06604104","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"VFiA","age_range":"60 Years","comparator":null,"organization":"University of Edinburgh","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Visual frailty — Within the first day of enrollment into the study.","Visual acuity — Within the first day of enrollment into the study.","Reading performance — Within the first day of enrollment into the study.","Functional status — Within the first day of enrollment into the study.","Mental health (Depression) — Within the first day of enrollment into the study.","Mental health (Anxiety) — Within the first day of enrollment into the study.","Mental health (Cognitive Impairment) — Within the first day of enrollment into the study.","Co-morbidities — Within the first day of enrollment into the study.","Physical frailty — Within the first day of enrollment into the study.","Correlation between visual frailty and physical frailty — This will be done immediately after assessment of both visual…","Correlation between Age-related macular degeneration and frailty — This will be done immediately after assessment of ph…","Perception about visual frailty — Within 4 weeks from the assessment date of visual frailty.","Expert opinion about visual frailty — From enrolment to the end of the study, an average of approximately 3 months."],"design_description":null,"source_has_results":false},"controlled_terms":["Frailty","Age-Related Macular Degeneration","Functional Status","Mental Health","Depression","Anxiety","Cognitive Impairment","Visual Impairment"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct06604104","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-04-09 to 2027-02-01","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.838Z","intervention":[],"participants":20,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Visual frailty — Within the first day of enrollment into the study.","Visual acuity — Within the first day of enrollment into the study.","Reading performance — Within the first day of enrollment into the study.","Functional status — Within the first day of enrollment into the study.","Mental health (Depression) — Within the first day of enrollment into the study.","Mental health (Anxiety) — Within the first day of enrollment into the study.","Mental health (Cognitive Impairment) — Within the first day of enrollment into the study.","Co-morbidities — Within the first day of enrollment into the study.","Physical frailty — Within the first day of enrollment into the study.","Correlation between visual frailty and physical frailty — This will be done immediately after assessment of both visual…","Correlation between Age-related macular degeneration and frailty — This will be done immediately after assessment of ph…","Perception about visual frailty — Within 4 weeks from the assessment date of visual frailty.","Expert opinion about visual frailty — From enrolment to the end of the study, an average of approximately 3 months."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: ageing, frailty.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}},{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: ageing, frailty.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34985","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}