{"type":"trials","record":{"id":35,"source_id":"clinicaltrials-gov","external_id":"NCT03072485","title":"Phase 1 Study of the Effects of Combining Topical FDA-approved Drugs on Age-related Pathways on the Skin of Healthy Volunteers","brief_summary":"This is a phase 1 study in healthy adult volunteers to examine the effects of 3 FDA approved medications on skin aging when applied in topical form. This is an open label, placebo controlled study.","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Anne Chang","enrollment":10,"countries":["United States"],"start_date":"2017-03-01","completion_date":"2019-02-22","last_update_date":"2019-04-01","source_url":"https://clinicaltrials.gov/study/NCT03072485","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:44:58.543517+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"55 Years","comparator":null,"organization":"Stanford University","interventions":["Sirolimus","Metformin","Diclofenac"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Profile of gene transcript changes — 4 weeks","Wrinkle score — 4 weeks"],"design_description":"NON RANDOMIZED · SEQUENTIAL · BASIC SCIENCE · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Sirolimus","Metformin","Diclofenac"],"relevance_confidence":70,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Source terminology contains: metformin.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct03072485","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-03-01 to 2019-02-22","comparator":null,"confidence":"structured-source","population":"FEMALE · 55 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.599Z","intervention":["Sirolimus","Metformin","Diclofenac"],"participants":10,"study_design":"NON RANDOMIZED · SEQUENTIAL · BASIC SCIENCE · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Profile of gene transcript changes — 4 weeks","Wrinkle score — 4 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Source terminology contains: metformin.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","title context","study type"],"relevance_score":70,"intelligence_topics":{"name":"Metformin","slug":"metformin"}},{"topic_slug":"rapamycin","is_published":true,"match_reasons":["Source terminology contains: sirolimus.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","title context","study type"],"relevance_score":70,"intelligence_topics":{"name":"Rapamycin","slug":"rapamycin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}