{"type":"trials","record":{"id":35003,"source_id":"clinicaltrials-gov","external_id":"NCT07429630","title":"Predictors of Physical Improvement in Frail Hospitalized Elders After Nutrition and Exercise","brief_summary":"This study aims to evaluate whether a 12-week program combining oral nutritional supplements (ONS) with resistance exercises can improve nutritional status, muscle strength, and physical mobility in hospitalized older adults with frailty. The investigators will enroll about 120 frail older inpatients in a single-group design. All participants will receive 90 grams of ONS daily and undergo supervised resistance training five times per week for 12 weeks. Nutrition, physical function, and frailty levels will be assessed before and after the intervention. Baseline characteristics will be examined as potential predictors of intervention response.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Zhejiang Hospital","enrollment":120,"countries":["China"],"start_date":"2023-03-21","completion_date":"2023-12-31","last_update_date":"2026-02-24","source_url":"https://clinicaltrials.gov/study/NCT07429630","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"Zhejiang Hospital","interventions":["Combined ONS and Resistance Training Program"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Fried frailty phenotype (FP) score — Baseline; At 12 weeks post-intervention","short physical performance battery (SPPB) score — Baseline; At 12 weeks post-intervention","mini nutritional assessment-short form(MNA-SF) score — Baseline; At 12 weeks post-intervention","body mass index (BMI) — Baseline; At 12 weeks post-intervention","activities of daily living (ADL) score — Baseline; At 12 weeks post-intervention","instrumental activities of daily living (IADL) score — Baseline; At 12 weeks post-intervention","performance-oriented mobility assessment (POMA) score — Baseline; At 12 weeks post-intervention","grip strength — Baseline; At 12 weeks post-intervention","serum level of transferrin (TFN) — Baseline; At 12 weeks post-intervention","serum level of prealbumin (PA) — Baseline; At 12 weeks post-intervention","serum level of albumin (ALB) — Baseline; At 12 weeks post-intervention"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Frail Elderly People Hospitalized","Combined ONS and Resistance Training Program"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07429630","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-03-21 to 2023-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.460Z","intervention":["Combined ONS and Resistance Training Program"],"participants":120,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Fried frailty phenotype (FP) score — Baseline; At 12 weeks post-intervention","short physical performance battery (SPPB) score — Baseline; At 12 weeks post-intervention","mini nutritional assessment-short form(MNA-SF) score — Baseline; At 12 weeks post-intervention","body mass index (BMI) — Baseline; At 12 weeks post-intervention","activities of daily living (ADL) score — Baseline; At 12 weeks post-intervention","instrumental activities of daily living (IADL) score — Baseline; At 12 weeks post-intervention","performance-oriented mobility assessment (POMA) score — Baseline; At 12 weeks post-intervention","grip strength — Baseline; At 12 weeks post-intervention","serum level of transferrin (TFN) — Baseline; At 12 weeks post-intervention","serum level of prealbumin (PA) — Baseline; At 12 weeks post-intervention","serum level of albumin (ALB) — Baseline; At 12 weeks post-intervention"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Title supplies longevity context: frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35003","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}