{"type":"trials","record":{"id":35188,"source_id":"clinicaltrials-gov","external_id":"NCT07159321","title":"Frailty and Health-related Quality of Life in Older Women With Breast Carcinoma","brief_summary":"This study addresses a critical gap in the care of older women with breast cancer, a population often underrepresented in clinical research despite their increased vulnerability to treatment-related complications. By examining the relationship between frailty and health-related quality of life (QOL), the study aims to provide evidence-based insights into how geriatric assessments can guide personalized treatment decisions, ensuring that therapeutic benefits outweigh risks. Given that older adults prioritize QOL over survival gains, understanding the impact of frailty on their well-being can help clinicians optimize care plans, reduce adverse outcomes, and improve overall patient-centered outcomes. The findings may also inform the integration of routine geriatric assessments in oncology practice, ultimately enhancing the management of older cancer patients in resource-limited settings like Egypt.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Ain Shams University","enrollment":100,"countries":[],"start_date":"2025-09-01","completion_date":"2026-09-30","last_update_date":"2025-09-08","source_url":"https://clinicaltrials.gov/study/NCT07159321","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"60 Years","comparator":null,"organization":"Ain Shams University","interventions":["Comprehensive geriatric assessment","European Organization for Research and Treatment-Quality of life questionnaire","Clinical Frailty Scale"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in the Quality of life measured by European Organization for Research and Treatment of Cancer Quality of Life Qu…","change in Frailty status as assessed by clinical frailty scale — 6 months"],"design_description":null,"source_has_results":false},"controlled_terms":["Breast Cancer Females","Frailty","Comprehensive geriatric assessment","European Organization for Research and Treatment-Quality of life questionnaire","Clinical Frailty Scale"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07159321","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-09-01 to 2026-09-30","comparator":null,"confidence":"structured-source","population":"FEMALE · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.487Z","intervention":["Comprehensive geriatric assessment","European Organization for Research and Treatment-Quality of life questionnaire","Clinical Frailty Scale"],"participants":100,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in the Quality of life measured by European Organization for Research and Treatment of Cancer Quality of Life Qu…","change in Frailty status as assessed by clinical frailty scale — 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35188","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}