{"type":"trials","record":{"id":35198,"source_id":"clinicaltrials-gov","external_id":"NCT06700291","title":"Preoperative Frailty and Postoperative Neurocognitive Disorders in Geriatric Patients in Georgia","brief_summary":"The number of elderly people in the global population is growing, presenting an increasing challenge. Technological advances in medicine have made it possible to perform complex surgeries on geriatric patients, improving the viability of this age group. However, postoperative neurocognitive disorders represent the most common postoperative complications in this demographic, leading to increased morbidity and mortality, a reduced quality of life, and a heightened risk of dementia. In high-income countries, studies have shown that preoperative frailty is associated with a cascade of postoperative disorders, including cognitive decline, delirium, dementia, and mortality. These complications negatively impact the community as a whole, healthcare staff and services, and the daily lives of those affected and their families. Perioperative neurocognitive disorders are linked to longer hospital stays, increased economic costs, reduced ability to work, and adverse consequences for family members and caregivers. Frailty is a syndrome characterized by decreased reserve and resistance to stressors, resulting from cumulative declines in multiple physiological systems over time. This leaves individuals less capable of mounting a satisfactory response to stressful events. Frailty is most prevalent in the aging population, with its prevalence increasing exponentially with age. This study will be the first to investigate preoperative frailty and its association with postoperative cognitive disorders in Georgia. Currently, there is limited information regarding the geriatric population in Georgia. The study will explore the prevalence of preoperative frailty and its impact on postoperative outcomes, including depression, dementia, cognitive dysfunction, delirium, and mortality at 30 days, three months, and one year following anesthesia and surgery. This pioneering research will provide valuable insights into these disorders in low- and middle-income countries. It will fill a significant gap in the international literature by contributing essential knowledge that is currently lacking in this field.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"New Hospitals Georgia","enrollment":230,"countries":["Georgia"],"start_date":"2023-04-26","completion_date":"2026-04-09","last_update_date":"2025-08-29","source_url":"https://clinicaltrials.gov/study/NCT06700291","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"FRAILCOG-GE","age_range":"65 Years","comparator":null,"organization":"New Hospitals Georgia","interventions":["Surgery"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Determine the prevalence of preoperative frailty — Frailty assessments will be conducted at baseline preoperatively, on…","Correlation between preoperative frailty and postoperative disorders (postoperative delirium, delayed neurocognitive re…","Preoperative demographics and risk factors, including but not limited to age, level of education, and comorbidities, an…","Prevalence of preoperative cognitive impairment — MoCA and TICSm - preoperative;","Correlation between preoperative cognitive impairment and postoperative disorders (postoperative delirium, delayed neur…","Determine the prevalence of depression in older adults presenting for anesthesia and surgery. — Assessment time points:…","Preoperative depression in older adults in Georgia presenting for anesthesia and surgery correlation with postoperative…","To determine the mortality rate up to one year after anesthesia and surgery — In hospital,1 months, 3 months and 12 mon…","Patient disability change among older adults in Georgia from the preoperative to postoperative period using WHO Disabil…","Patient quality of life change among older adults in Georgia from the preoperative to postoperative period using Daily…"],"design_description":null,"source_has_results":false},"controlled_terms":["Frailty","Surgery"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06700291","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-04-26 to 2026-04-09","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.489Z","intervention":["Surgery"],"participants":230,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Determine the prevalence of preoperative frailty — Frailty assessments will be conducted at baseline preoperatively, on…","Correlation between preoperative frailty and postoperative disorders (postoperative delirium, delayed neurocognitive re…","Preoperative demographics and risk factors, including but not limited to age, level of education, and comorbidities, an…","Prevalence of preoperative cognitive impairment — MoCA and TICSm - preoperative;","Correlation between preoperative cognitive impairment and postoperative disorders (postoperative delirium, delayed neur…","Determine the prevalence of depression in older adults presenting for anesthesia and surgery. — Assessment time points:…","Preoperative depression in older adults in Georgia presenting for anesthesia and surgery correlation with postoperative…","To determine the mortality rate up to one year after anesthesia and surgery — In hospital,1 months, 3 months and 12 mon…","Patient disability change among older adults in Georgia from the preoperative to postoperative period using WHO Disabil…","Patient quality of life change among older adults in Georgia from the preoperative to postoperative period using Daily…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35198","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}