{"type":"trials","record":{"id":35207,"source_id":"clinicaltrials-gov","external_id":"NCT07134439","title":"Identifying Fundamental Mechanisms of Skeletal Muscle Ageing in Older Men Undergoing Androgen Deprivation Therapy: a Feasibility Study","brief_summary":"To find out whether it is possible to run a study looking at the underlying markers of ageing in muscle quality and quantity in men receiving Androgen Deprivation Therapy for prostate cancer treatment. To determine the feasibility of conducting an observational study examining the association of fundamental biological markers of ageing with changes in body composition and skeletal muscle morphology following ADT in older men undergoing prostate cancer treatment.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Guy's and St Thomas' NHS Foundation Trust","enrollment":20,"countries":[],"start_date":"2025-09-01","completion_date":"2026-12-01","last_update_date":"2025-08-21","source_url":"https://clinicaltrials.gov/study/NCT07134439","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"MALE","acronym":"MASS-ADT","age_range":"65 Years","comparator":null,"organization":"Guy's and St Thomas' NHS Foundation Trust","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Recruitment and retention rate — 6 months","Rectus femoris ultrasound echogenicity at four-six months, adjusting for baseline echogenicity readings. — 6 months","Ultrasound Bilateral Anterior Thigh Thickness (BATT) at four-six months, adjusting for baseline BATT — 6 months","Bilateral anterior thigh subcutaneous tissue thickness at four-six months, adjusting for baseline thickness — 6 months","Skeletal muscle mass (SMM) assessed using bioelectrical impedance analysis (BIA) at four-six months, adjusting for base…","Fat mass from BIA at four-six months, adjusting for baseline fat mass — 6 months","Handgrip strength at four-six months, adjusting for baseline strength — 6 months","Quadriceps strength outcomes using isokinetic dynamometry, adjusting for baseline strength — 6 months","Short physical performance battery (SPPB) at four-six months, adjusting for baseline SPPB — 6 months","Lower limb muscular power measured by the vertical jump test at four-six months, adjusting for baseline power — 6 months","European Organisation For Research And Treatment Of Cancer (EORTC) Core Quality of Life questionnaire score at four-six…","Biological markers of accelerated ageing — 6 months","Frailty level — 6 months"],"design_description":null,"source_has_results":false},"controlled_terms":["Sarcopenia","Prostate Cancer","Muscle Atrophy","Androgen Deprivation Therapy"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: muscle ageing.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07134439","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-09-01 to 2026-12-01","comparator":null,"confidence":"structured-source","population":"MALE · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.815Z","intervention":[],"participants":20,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Recruitment and retention rate — 6 months","Rectus femoris ultrasound echogenicity at four-six months, adjusting for baseline echogenicity readings. — 6 months","Ultrasound Bilateral Anterior Thigh Thickness (BATT) at four-six months, adjusting for baseline BATT — 6 months","Bilateral anterior thigh subcutaneous tissue thickness at four-six months, adjusting for baseline thickness — 6 months","Skeletal muscle mass (SMM) assessed using bioelectrical impedance analysis (BIA) at four-six months, adjusting for base…","Fat mass from BIA at four-six months, adjusting for baseline fat mass — 6 months","Handgrip strength at four-six months, adjusting for baseline strength — 6 months","Quadriceps strength outcomes using isokinetic dynamometry, adjusting for baseline strength — 6 months","Short physical performance battery (SPPB) at four-six months, adjusting for baseline SPPB — 6 months","Lower limb muscular power measured by the vertical jump test at four-six months, adjusting for baseline power — 6 months","European Organisation For Research And Treatment Of Cancer (EORTC) Core Quality of Life questionnaire score at four-six…","Biological markers of accelerated ageing — 6 months","Frailty level — 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: muscle ageing.","Source terminology contains: sarcopenia.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35207","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}