{"type":"trials","record":{"id":35285,"source_id":"clinicaltrials-gov","external_id":"NCT06324149","title":"Age-related Conditions in the Context of Multimorbidity and Frailty: Relative Weight of Frailty in Determining the Course and Outcomes of Different Chronic Diseases and Viceversa","brief_summary":"Observational study. Participants of the FRASNET study (9th March 2017, Protocol No. 24/INT/2017) who were evaluated in 2016 and 2017 will be contacted to be re-evaluated with multidimensional visits as part of the present study in order to assess trajectories and biomarkers of frailty and sarcopenia. Moreover, are going to evaluate with the same multidimensional visits patients with mild cognitive impairment and dementia followed up at the Neurologic Unit of the San Raffaele Hospital.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"IRCCS San Raffaele","enrollment":500,"countries":["Italy"],"start_date":"2024-03-07","completion_date":"2026-04-30","last_update_date":"2025-06-22","source_url":"https://clinicaltrials.gov/study/NCT06324149","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:25:30.723+00:00","metadata":{"sex":"ALL","acronym":"AGE-IT-FRAILTY","age_range":"18 Years to 100 Years","comparator":null,"organization":"IRCCS San Raffaele","interventions":["completion of scales and questionnaires; venous blood sampling; muscle ultrasound; cardiac ultrasound; electrocardiogra…"],"registry_source":"ClinicalTrials.gov","outcome_measures":["identify new molecular markers of frailty and sarcopenia — febbrary 2026","evaluate the ability of new markers for frailty, sarcopenia, cognitive impairment — april 2026"],"design_description":null,"source_has_results":false},"controlled_terms":["Frailty","Sarcopenia","completion of scales and questionnaires; venous blood sampling; muscle ultrasound; cardiac ultrasound; electrocardiogra…"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:25:35.871646+00:00","duplicate_cluster_key":"id:nct06324149","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-03-07 to 2026-04-30","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 100 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:30.741Z","intervention":["completion of scales and questionnaires; venous blood sampling; muscle ultrasound; cardiac ultrasound; electrocardiogra…"],"participants":500,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["identify new molecular markers of frailty and sarcopenia — febbrary 2026","evaluate the ability of new markers for frailty, sarcopenia, cognitive impairment — april 2026"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}},{"topic_slug":"multimorbidity","is_published":true,"match_reasons":["Title contains controlled term: multimorbidity.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Multimorbidity","slug":"multimorbidity"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35285","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}