{"type":"trials","record":{"id":35289,"source_id":"clinicaltrials-gov","external_id":"NCT07027241","title":"Frailty Intervention in Postoperative Hip Fracture Inpatients","brief_summary":"Hip fracture is a big health concern in older adults, and can lead to increased risk of death, reduced level of independence \\& mobility, reduced quality of life, and higher likelihood of admission to nursing homes. Frailty is a medical condition associated with ageing that results in a reduced ability to do daily tasks. A frail older adult is also less able to recover well from conditions that may affect their wellbeing (for example, infections, falls resulting in injuries or hospital admissions). Frailty is common in older adults with hip fractures. There has been increasing research showing that frailty can be slowed down and improved by a combination of nutritional supplementation and exercise. However, most of the research in this area has been in frail older adults living at home or in nursing homes. The exercise or nutritional programs in these studies tend to be carried out over weeks or months. There are very few studies looking at older adults in hospital and how exercise and nutrition help with frailty over shorter periods of time, even more so in patients who have sustained an injury. There is, however, very little research in hospital based frailty programs in older patients who have suffered major trauma. It is well known that standing up and starting to walk soon after a hip fracture improves time to recovery, reduces hospital length of stay and death. Hence, physiotherapy on the first day after hip fracture surgery is now recommended. However, there needs to be more research to aid in developing physiotherapy and exercise programs that are safe and doable in the care of hip fracture patients despite limited resources in our healthcare system. Similarly, although malnutrition is common in frail older adults with hip fractures, the benefits of nutritional supplementation in these patients is not fully understood. It is known that having a hip fracture puts a person at risk of muscle breakdown and increasing protein intake is recommended to help reduce this risk. Research on exercise and nutrition based frailty programs specific to hip fracture patients is strongly needed, specifically the development of that are doable and safe in the hospital setting that can help improve outcomes in hip fracture patients after surgery. The investigators believe that a multicomponent exercise and nutrition based frailty program will be safe, doable and acceptable in frail older adults after hip fracture surgery.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Royal College of Surgeons, Ireland","enrollment":50,"countries":["Ireland"],"start_date":"2025-08-01","completion_date":"2026-02-01","last_update_date":"2025-06-18","source_url":"https://clinicaltrials.gov/study/NCT07027241","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"Usual Care","organization":"Royal College of Surgeons, Ireland","interventions":["Exercise Intervention","Usual Care","Nutritional Intervention"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Eligibility Rate — Through study completion, an average of 6 months","Recruitment Rate — Through study completion, an average of 6 months","Number of drop outs — Through study completion, an average fo 6 months","Number of intervention related adverse events — Through study completion, an average of 6 months","Compliance to prescribed duration of exercise sessions — Through completion of intervention, an average of 3 weeks up t…","Patient Acceptability of Intervention — Through study completion, an average of 6 months","Nursing staff acceptability of intervention delivery — Through study completion, an average of 6 months","Compliance with prescribed intensity — Through completion of intervention, an average of 3 weeks up to a maximum of 6 w…","Attendance rate — Through completion of intervention, an average of 3 weeks up to a maximum of 6 weeks","Compliance rate to prescribed nutritional intervention — Through completion of intervention, an average of 3 weeks up t…","Cumulative Ambulation Score (CAS) — At baseline and within 48 hours of discharge from hospital","Grip strength (Dominant hand) — At baseline and within 48 hours of discharge from hospital","Verbal Rating Scale for Pain (VRS) — At baseline and within 48 hours of discharge from hospital","Functional Independence Measure (FIM) — At baseline and within 48 hours of discharge from hospital","Barthel Index — At baseline and within 48 hours of discharge from hospital","Length of Stay (LOS) in hospital — Through intervention completion, an average of 3 weeks up to a maximum of 6 weeks fo…","Discharge Destination — Through intervention completion, an average of 3 weeks up to a maximum of 6 weeks for prolonged…","Health related quality of life (HRQoL) — At baseline and 30 days post discharge","Upright and Sedentary Events — Throughout inpatient stay, average of 3 weeks up to a maximum of 6 weeks","Depression — At baseline and within 48 hours of discharge from hospital"],"design_description":"NON RANDOMIZED · FACTORIAL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Hip Fractures (ICD-10 72.01-72.2)","Frailty at Older Adults","Strength Training","Resistance Training","Exercise Training","Protein Supplementation","Exercise Intervention","Usual Care","Nutritional Intervention"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07027241","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-08-01 to 2026-02-01","comparator":"Usual Care","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.504Z","intervention":["Exercise Intervention","Usual Care","Nutritional Intervention"],"participants":50,"study_design":"NON RANDOMIZED · FACTORIAL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Eligibility Rate — Through study completion, an average of 6 months","Recruitment Rate — Through study completion, an average of 6 months","Number of drop outs — Through study completion, an average fo 6 months","Number of intervention related adverse events — Through study completion, an average of 6 months","Compliance to prescribed duration of exercise sessions — Through completion of intervention, an average of 3 weeks up t…","Patient Acceptability of Intervention — Through study completion, an average of 6 months","Nursing staff acceptability of intervention delivery — Through study completion, an average of 6 months","Compliance with prescribed intensity — Through completion of intervention, an average of 3 weeks up to a maximum of 6 w…","Attendance rate — Through completion of intervention, an average of 3 weeks up to a maximum of 6 weeks","Compliance rate to prescribed nutritional intervention — Through completion of intervention, an average of 3 weeks up t…","Cumulative Ambulation Score (CAS) — At baseline and within 48 hours of discharge from hospital","Grip strength (Dominant hand) — At baseline and within 48 hours of discharge from hospital","Verbal Rating Scale for Pain (VRS) — At baseline and within 48 hours of discharge from hospital","Functional Independence Measure (FIM) — At baseline and within 48 hours of discharge from hospital","Barthel Index — At baseline and within 48 hours of discharge from hospital","Length of Stay (LOS) in hospital — Through intervention completion, an average of 3 weeks up to a maximum of 6 weeks fo…","Discharge Destination — Through intervention completion, an average of 3 weeks up to a maximum of 6 weeks for prolonged…","Health related quality of life (HRQoL) — At baseline and 30 days post discharge","Upright and Sedentary Events — Throughout inpatient stay, average of 3 weeks up to a maximum of 6 weeks","Depression — At baseline and within 48 hours of discharge from hospital"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35289","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}