{"type":"trials","record":{"id":35312,"source_id":"clinicaltrials-gov","external_id":"NCT05946174","title":"Tackling Disruptions to Frailty Interventions: Developing Personalized Interventions Targeted for Older Persons With Cardiac Frailty","brief_summary":"Background: Muscle mass loss and metabolic dysfunction, exacerbated by inactivity and nutritional inadequacies, underpin both cardiovascular disease and frailty in ageing. The investigators' proposal seeks to develop interventions in exercise and diet that are targeted for older adults with cardiac frailty. Methods: The investigators' proposal is a five-year study comprising of first phase (first 2-2.5 years) and second phase (next 2-2.5 years). In the first phase cardiac frail participants (up to N=500) from each healthcare transition (inpatient hospital, step-down community hospital, outpatient clinic/community) will be randomized to receive Intervention Sets or usual care. The second phase will scale up these programs. Three Intervention Sets A, B, and C will be implemented in the outpatient, step-down community hospital, and acute hospital settings. Diet intervention comprises meal sets prepared with nutrients involved in energy metabolism. Exercise training is facilitated by hospital gyms and hospital physiotherapists. Diet and exercise behavior will be monitored using questionnaires, video conferencing and meal photos. Significance: Clinical studies are urgently needed using consistent frailty tools to evaluate the efficacy and promise of frailty interventions, targeted to achieve reversal/retardation of frailty. When scaled up, these approaches will provide high-quality science needed to manage cardiac frailty towards healthier population ageing.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National Heart Centre Singapore","enrollment":500,"countries":["Singapore"],"start_date":"2023-07-12","completion_date":"2028-06-21","last_update_date":"2025-06-05","source_url":"https://clinicaltrials.gov/study/NCT05946174","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"INDEPENDENCY","age_range":"21 Years to 100 Years","comparator":"Outpatient clinic/community participants receiving control/usual care (A2); Step-down community hospital participants receiving control/usual care (B2); Acute hospital participants receiving control/usual care (C2)","organization":"National Heart Centre Singapore","interventions":["Intervention Set A","Intervention Set B","Intervention Set C"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Improvement in cardiovascular markers — at 14 weeks from baseline","Improvement in skeletal muscle — at 14 weeks from baseline","Improvement in Fried Frailty Phenotype Score (improvement in any domain) (i.e., reduction in score) — at six months fro…","Improvement in metabolite level — Three months and six months from baseline","Improvement in Quality of life (QOL): EuroQOL-5D-5L (higher score) — Three months and six months from baseline"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Cardiovascular Diseases","Intervention Set A","Intervention Set B","Intervention Set C"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct05946174","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-07-12 to 2028-06-21","comparator":"Outpatient clinic/community participants receiving control/usual care (A2); Step-down community hospital participants receiving control/usual care (B2); Acute hospital participants receiving control/usual care (C2)","confidence":"structured-source","population":"ALL · 21 Years to 100 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.506Z","intervention":["Intervention Set A","Intervention Set B","Intervention Set C"],"participants":500,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Improvement in cardiovascular markers — at 14 weeks from baseline","Improvement in skeletal muscle — at 14 weeks from baseline","Improvement in Fried Frailty Phenotype Score (improvement in any domain) (i.e., reduction in score) — at six months fro…","Improvement in metabolite level — Three months and six months from baseline","Improvement in Quality of life (QOL): EuroQOL-5D-5L (higher score) — Three months and six months from baseline"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35312","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}