{"type":"trials","record":{"id":35325,"source_id":"clinicaltrials-gov","external_id":"NCT04692233","title":"Qigong to Improve Frailty Among Older Cancer Survivors","brief_summary":"The objective of the study is to examine the effects of a 16-week Baduanjin qigong intervention on frailty, physical performance, psychological well-being, and health-related quality of life (HRQoL) among post-treatment older cancer survivors. This will be a randomized controlled, assessor-blind trial conforming to the CONSORT guidelines. A total of 226 cancer survivors aged over 65 who have completed curative treatment and screened as pre-frail or frail will be recruited and randomized into intervention and control groups. It is expected that upon intervention completion, the intervention group will demonstrate greater reversed frailty status, more improvements in physical performance, better psychological well-being, and enhanced HRQoL compared to the control group. Study instruments will be Fried Phenotype Criteria, Edmonton Frail Scale, Short Physical Performance Battery, Geriatric Depression Scale, European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire, and a background questionnaire. The intervention comprises of 1-hour qigong group training twice a week for 8 weeks, then 1-hour weekly follow-up group practice for 8 weeks and self-practice. The control group participants will attend light flexibility exercise group sessions at the same duration and frequency as the intervention group. Intention-to-treat analysis will be performed.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"The University of Hong Kong","enrollment":226,"countries":["Hong Kong"],"start_date":"2021-02-19","completion_date":"2024-07-31","last_update_date":"2025-05-28","source_url":"https://clinicaltrials.gov/study/NCT04692233","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"Light flexibility exercise","organization":"The University of Hong Kong","interventions":["Qigong Baduanjin","Light flexibility exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Improvement in frailty status — at study entry, post-training, post-intervention, 6 months post intervention, 12 months…","Improvement in frailty scores — at study entry, post-training, post-intervention, 6 months post intervention, 12 months…","Physical performance — at study entry, post-training, post-intervention, 6 months post intervention, 12 months post int…","Psychological well-being — at study entry, post-training, post-intervention, 6 months post intervention, 12 months post…","Health-related quality of life — at study entry, post-training, post-intervention, 6 months post intervention, 12 month…"],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · SINGLE","source_has_results":false},"controlled_terms":["Cancer","Frailty","Survivorship","Elderly","Qigong Baduanjin","Light flexibility exercise"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct04692233","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-02-19 to 2024-07-31","comparator":"Light flexibility exercise","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.508Z","intervention":["Qigong Baduanjin","Light flexibility exercise"],"participants":226,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Improvement in frailty status — at study entry, post-training, post-intervention, 6 months post intervention, 12 months…","Improvement in frailty scores — at study entry, post-training, post-intervention, 6 months post intervention, 12 months…","Physical performance — at study entry, post-training, post-intervention, 6 months post intervention, 12 months post int…","Psychological well-being — at study entry, post-training, post-intervention, 6 months post intervention, 12 months post…","Health-related quality of life — at study entry, post-training, post-intervention, 6 months post intervention, 12 month…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35325","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}