{"type":"trials","record":{"id":35339,"source_id":"clinicaltrials-gov","external_id":"NCT06975540","title":"Synergy of Exercise and Nutrition in Preventing and Treating Frailty","brief_summary":"The goal of this clinical study is to learn if combining a nutritional supplement with a multicomponent exercise program can help prevent and treat frailty in community dwelling older adults. The main questions it aims to answer is: Does combining a nutritional supplement (MERITENE) with a multicomponent exercise program improve frailty and functionality in older adults? Researchers will compare: * A group receiving both the nutritional supplement and the exercise program (intervention group) * A control group receiving neither (control group) Participants: * take the nutritional supplement (MERITENE, 30g twice a day) for 180 days * attend (3days/week) supervised exercise sessions as part of the multicomponent program for 180 days (if assigned to the intervention group). * undergo regular clinical evaluations for frailty, nutritional status, cognitive function, emotional state, and quality of life. Measurements will include: Changes in frailty status, particularly gait speed, measured using Share-fi criteria, nutritional assessment using the Mini Nutritional Assessment (MNA), physical and cognitive assessments, including Edmonton Frail Scale, MMSE, and Short Physical Performance Battery (SPPB) and a complete biochemical and clinical blood analysis.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Fundación para la Investigación del Hospital Clínico de Valencia","enrollment":47,"countries":["Spain"],"start_date":"2019-10-14","completion_date":"2022-07-29","last_update_date":"2025-05-16","source_url":"https://clinicaltrials.gov/study/NCT06975540","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"ROBUSTNES","age_range":"70 Years","comparator":"Control","organization":"Fundación para la Investigación del Hospital Clínico de Valencia","interventions":["Multidomain physical exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Frailty according to the Survey of Health, Ageing and Retirement in Europe Frailty Index (SHARE-FI) — 24 weeks (180 day…"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Frail Elderly","Multidomain physical exercise"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06975540","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-10-14 to 2022-07-29","comparator":"Control","confidence":"structured-source","population":"ALL · 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.510Z","intervention":["Multidomain physical exercise"],"participants":47,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Frailty according to the Survey of Health, Ageing and Retirement in Europe Frailty Index (SHARE-FI) — 24 weeks (180 day…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35339","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}