{"type":"trials","record":{"id":35344,"source_id":"clinicaltrials-gov","external_id":"NCT03636412","title":"Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients","brief_summary":"The objective of this study is to assess the feasibility and effectiveness of dedicated ambulator-assisted physical activity in lung transplant inpatients. The primary hypothesis is that an ambulator-assisted intervention for lung transplant patients will prove feasible and may result in improved frailty, hospital outcomes, including less need for inpatient rehabilitation and shorter length of stay in the hospital.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"The Cleveland Clinic","enrollment":200,"countries":["United States"],"start_date":"2018-08-15","completion_date":"2024-12-31","last_update_date":"2025-05-14","source_url":"https://clinicaltrials.gov/study/NCT03636412","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":"iFRAIL","age_range":"18 Years","comparator":"No Ambulator","organization":"The Cleveland Clinic","interventions":["Ambulation"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Hospital Length of Stay — Through study completion, approximately 1 year post-transplant","Regular Nursing Floor Length of Stay — Through study completion, approximately 1 year post-transplant","30-day readmission — Up to 30 days following discharge","Change in physical frailty phenotype — pre-transplant to 1 year following transplant","Change in short physical performance battery — pre-transplant to 1 year following transplant","Change in AMPAC/6-click score — pre-transplant to 1 year following transplant","Change in sarcopenia — pre-transplant to 1 year following transplant","Change in nutritional status; serum albumin — pre-transplant to 1 year following transplant","Change in nutritional status; serum protein — pre-transplant to 1 year following transplant","Change in nutritional status; BMI — pre-transplant to 1 year following transplant","Change in eyeball frailty assessment — pre-transplant to 1 year following transplant","Presence of aspiration — pre-transplant to 1 year following transplant","Readmission to ICU — Through study completion, approximately 1 year post-transplant","In-hospital falls — Through study completion, approximately 1 year post-transplant","Aspiration event — Through study completion, approximately 1 year post-transplant","Graft survival — Through study completion, approximately 1 year post-transplant","Accelerometer step change — pre-transplant (weeks to a year to more) and immediately after transplant, up to 1 year pos…","Accelerometer energy expenditure — pre-transplant (weeks to a year to more) and immediately after transplant, up to 1 y…","Accelerometer time ambulating — pre-transplant (weeks to a year to more) and immediately after transplant, up to 1 year…"],"design_description":"NON RANDOMIZED · PARALLEL · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Transplant-Related Disorder","Frail Elderly Syndrome","Sarcopenia","Lung Graft Dysfunction","Mobility Limitation","Ambulation"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct03636412","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-08-15 to 2024-12-31","comparator":"No Ambulator","confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.824Z","intervention":["Ambulation"],"participants":200,"study_design":"NON RANDOMIZED · PARALLEL · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Hospital Length of Stay — Through study completion, approximately 1 year post-transplant","Regular Nursing Floor Length of Stay — Through study completion, approximately 1 year post-transplant","30-day readmission — Up to 30 days following discharge","Change in physical frailty phenotype — pre-transplant to 1 year following transplant","Change in short physical performance battery — pre-transplant to 1 year following transplant","Change in AMPAC/6-click score — pre-transplant to 1 year following transplant","Change in sarcopenia — pre-transplant to 1 year following transplant","Change in nutritional status; serum albumin — pre-transplant to 1 year following transplant","Change in nutritional status; serum protein — pre-transplant to 1 year following transplant","Change in nutritional status; BMI — pre-transplant to 1 year following transplant","Change in eyeball frailty assessment — pre-transplant to 1 year following transplant","Presence of aspiration — pre-transplant to 1 year following transplant","Readmission to ICU — Through study completion, approximately 1 year post-transplant","In-hospital falls — Through study completion, approximately 1 year post-transplant","Aspiration event — Through study completion, approximately 1 year post-transplant","Graft survival — Through study completion, approximately 1 year post-transplant","Accelerometer step change — pre-transplant (weeks to a year to more) and immediately after transplant, up to 1 year pos…","Accelerometer energy expenditure — pre-transplant (weeks to a year to more) and immediately after transplant, up to 1 y…","Accelerometer time ambulating — pre-transplant (weeks to a year to more) and immediately after transplant, up to 1 year…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35344","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}