{"type":"trials","record":{"id":35375,"source_id":"clinicaltrials-gov","external_id":"NCT06073106","title":"Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention","brief_summary":"The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems. This is due to a lack of normative data for older adults and reliable risk stratification methods to develop effective approaches to the prevention of frailty. In this study, the investigators plan to form a common dataset for phenotype identification, risk stratification of frailty and its targeted treatment plans in the at-risk and mildly frail population.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Tan Tock Seng Hospital","enrollment":500,"countries":["Singapore"],"start_date":"2025-01-01","completion_date":"2027-01-01","last_update_date":"2025-04-11","source_url":"https://clinicaltrials.gov/study/NCT06073106","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:25:30.723+00:00","metadata":{"sex":"ALL","acronym":"OPTIMA-C","age_range":"50 Years","comparator":null,"organization":"Tan Tock Seng Hospital","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Incidence (rates) of Frailty — Through study's data collection period, up to 4 years","Severity of Frailty — For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd year); For outpatient…","Body Composition Analysis (BCA) — For inpatient: Visit 3 (6 months post-event) to Visit 6 (end of 3rd year); For outpat…","Short Physical Performance Battery (SPPB) — For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd…","Hand Grip Strength (kg) — For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd year); For outpat…","Muscle Ultrasound imaging — For Inpatient: Visit 1 (within 2 weeks of admission), Visit 2 (1 week pre-discharge)","FRAIL Questionnaire — For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd year); For outpatient…"],"design_description":null,"source_has_results":false},"controlled_terms":["Stroke","Traumatic Brain Injury","Knee Osteoarthritis","Breast Cancer"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:25:35.871646+00:00","duplicate_cluster_key":"id:nct06073106","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-01-01 to 2027-01-01","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:30.742Z","intervention":[],"participants":500,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Incidence (rates) of Frailty — Through study's data collection period, up to 4 years","Severity of Frailty — For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd year); For outpatient…","Body Composition Analysis (BCA) — For inpatient: Visit 3 (6 months post-event) to Visit 6 (end of 3rd year); For outpat…","Short Physical Performance Battery (SPPB) — For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd…","Hand Grip Strength (kg) — For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd year); For outpat…","Muscle Ultrasound imaging — For Inpatient: Visit 1 (within 2 weeks of admission), Visit 2 (1 week pre-discharge)","FRAIL Questionnaire — For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd year); For outpatient…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}},{"topic_slug":"multimorbidity","is_published":true,"match_reasons":["Title contains controlled term: multimorbidity.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Multimorbidity","slug":"multimorbidity"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35375","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}