{"type":"trials","record":{"id":35379,"source_id":"clinicaltrials-gov","external_id":"NCT05710809","title":"The SaVe Project-Sarcopenia and Vertigo in Aging Patients With Colorectal Cancer","brief_summary":"The goal of this clinical trial is to learn about the cause of dizziness and decline in walking ability in in older adults ≥65 years during chemotherapy treatment for colorectal cancer. Another goal is to investigate if a comprehensive geriatric assessment and three months' specialized physical group-based exercise three times/week can counteract muscle weakness, vertigo, instability, impaired walking balance, and neuropathy","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Rigshospitalet, Denmark","enrollment":150,"countries":["Denmark"],"start_date":"2023-02-20","completion_date":"2027-09-01","last_update_date":"2025-04-06","source_url":"https://clinicaltrials.gov/study/NCT05710809","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":"SaVe","age_range":"65 Years","comparator":"Usual care group","organization":"Rigshospitalet, Denmark","interventions":["Targeted specialized physical group-based exercise and Comprehensive Geriatric Assessement"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Dynamic Gait Index (DGI) — Three months","30 second Sit-to-Stand Test (30STS) — Three months","Falls — Baseline, two, four, six, eight, ten, twelve, fourteen, sixteen, eighteen, twenty, twenty-two, and twenty-four…","Hospital contacts due to falls — Baseline, three and six months","Balance disabilities/dizziness — Baseline, three and six months","Fear of falling — Baseline, three and six months","Health related quality of life — Baseline, three and six months","Peripheral nerve function — Baseline, three and six months","Autonomic function — Baseline, three and six months","Chemotherapy induced peripheral neuropathy — Baseline, three and six months","Muscle strength — Baseline, three and six months","Body composition — Baseline, three and six months"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Colorectal Cancer","Oncologic Complications","Comprehensive Geriatric Assessment","Vestibular Rehabilitation","Geriatric Oncology","Sarcopenia","Vertigo","Cancer","Rehabilitation","Exercise","Geriatric","Elderly","Frail","Older Adults","Chemotherapy","Chemotherapy-induced Peripheral Neuropathy","Resistance Training","Balance Training","Postural Stability","Pragmatic Trial","Personal Medicine","Individualised","Targeted specialized physical group-based exercise and Comprehensive Geriatric Assessement"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct05710809","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-02-20 to 2027-09-01","comparator":"Usual care group","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.827Z","intervention":["Targeted specialized physical group-based exercise and Comprehensive Geriatric Assessement"],"participants":150,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Dynamic Gait Index (DGI) — Three months","30 second Sit-to-Stand Test (30STS) — Three months","Falls — Baseline, two, four, six, eight, ten, twelve, fourteen, sixteen, eighteen, twenty, twenty-two, and twenty-four…","Hospital contacts due to falls — Baseline, three and six months","Balance disabilities/dizziness — Baseline, three and six months","Fear of falling — Baseline, three and six months","Health related quality of life — Baseline, three and six months","Peripheral nerve function — Baseline, three and six months","Autonomic function — Baseline, three and six months","Chemotherapy induced peripheral neuropathy — Baseline, three and six months","Muscle strength — Baseline, three and six months","Body composition — Baseline, three and six months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35379","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}