{"type":"trials","record":{"id":35406,"source_id":"clinicaltrials-gov","external_id":"NCT05795556","title":"Biomarkers of Sarcopenia and Frailty in Geriatric Patients","brief_summary":"During the last decades there has been an increase in the relative proportion and life expectancy of elderly people. Hence, the number of elderly with diseases and disabilities related to aging will increase and consequently, age-related losses in skeletal muscle mass and physical function represents an important current and future public health issue. Sarcopenia is a progressive and generalized skeletal muscle disorder that is considered central to the development of physical deconditioning and untreated sarcopenia is linked to falls, morbidity, and mortality. The underlying mechanisms behind the progressive loss of muscle mass and function associated with aging are yet unknown but seems to be multifactorial. A decrease in physical activity level and an altered central and peripheral nervous system innervation have been identified as some of the contributing factors. Furthermore, chronic low-grade inflammation has been proposed as a central contributor to sarcopenia and thus physical frailty. However, it is not yet clear whether the elevated markers of inflammation seen in the elderly are due to aging, chronic illness, or inactivity. But overall, it seems that inflammation plays an important role in the development of muscle loss, and is related to increased risk of falls, fragility, and early death.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Herlev and Gentofte Hospital","enrollment":508,"countries":["Denmark"],"start_date":"2021-11-08","completion_date":"2024-06-30","last_update_date":"2025-03-12","source_url":"https://clinicaltrials.gov/study/NCT05795556","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":"BioFrail","age_range":"65 Years","comparator":null,"organization":"Herlev and Gentofte Hospital","interventions":["Assessing sarcopenia and potential biomarkers of sarcopenia in fall patients"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Skeletal muscle mass — Baseline","Appendicular lean muscle mass — Baseline","Skeletal muscle mass index (SMI) — Baseline","Muscle Thickness — Baseline","Muscle strength (upper body) — Baseline","Muscle strength (lower body) — Baseline","Physical Activity (Chair rise) — Baseline","Physical Activity (Gait speed) — Baseline","Postural sway — Baseline","SARC-F (sarcopenia screening) — Baseline","Geriatric Depression Scale (GDS-15) — Baseline","SNAQ (malnutrition) — Baseline"],"design_description":null,"source_has_results":false},"controlled_terms":["Sarcopenia","Muscle Loss","Fall Patients","Assessing sarcopenia and potential biomarkers of sarcopenia in fall patients"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct05795556","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-11-08 to 2024-06-30","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.831Z","intervention":["Assessing sarcopenia and potential biomarkers of sarcopenia in fall patients"],"participants":508,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Skeletal muscle mass — Baseline","Appendicular lean muscle mass — Baseline","Skeletal muscle mass index (SMI) — Baseline","Muscle Thickness — Baseline","Muscle strength (upper body) — Baseline","Muscle strength (lower body) — Baseline","Physical Activity (Chair rise) — Baseline","Physical Activity (Gait speed) — Baseline","Postural sway — Baseline","SARC-F (sarcopenia screening) — Baseline","Geriatric Depression Scale (GDS-15) — Baseline","SNAQ (malnutrition) — Baseline"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}},{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35406","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}