{"type":"trials","record":{"id":35427,"source_id":"clinicaltrials-gov","external_id":"NCT04418271","title":"Prehabilitation of Elderly Patients With Frailty Syndrome Before Elective Surgery (PRAEP-GO)","brief_summary":"The aim of the study is to evaluate the effect of a shared decision-making conference and three-week prehabilitation program on the outcome \"care dependency\" one year after surgery. The cost-effectiveness of the intervention will also be evaluated in this N = 1400 patient, national multicenter, assessor-blinded, randomized, pragmatic, controlled, parallel-group, clinical trial. The objective of PRÄP-GO is to establish and employ a suitable preoperative case-care management system to improve the short and long-term outcome of elderly surgical patients with signs of a frailty syndrome, improving postoperative quality of life and reducing care dependency by a three-week individualized prehabilitation program.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Charite University, Berlin, Germany","enrollment":1199,"countries":["Germany"],"start_date":"2020-06-30","completion_date":"2024-12-19","last_update_date":"2025-02-19","source_url":"https://clinicaltrials.gov/study/NCT04418271","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"70 Years","comparator":"Standard of Care","organization":"Charite University, Berlin, Germany","interventions":["Prehabilitation- new form of care"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Degree of care dependency — Up to one year","Barthel Index — Up to one year","Change in NBA score — Up to one year","NBA domain change — Up to one year","Surrogate for Neurocognitive Disorder (NCD) — Up to one year","Screening tool for cognitive vulnerability — Up to one year","Dementia risk assessed by MOCA — Up to one year","Delirium — Up to one year","Frailty — Up to one year","Perioperative complications by Clavien-Dindo — Up to hospital discharge","Every mobility — Up to one year","Autonomy Preference — At the beginning of the observation","Extent of involvement in shared decision-making process — At the beginning of the observation","Arm circumference — Up to one year","Calf circumference — Up to one year","Nutritional Status — Up to one year","Change in body weight — Up to one year","Instrumental Activities of daily living (IADL) — Up to one year","Functional endurance — Up to one year","Function of the respiratory system — Up to one year"],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · NONE","source_has_results":false},"controlled_terms":["Frailty","Frail Elderly","Prehabilitation- new form of care"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct04418271","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-06-30 to 2024-12-19","comparator":"Standard of Care","confidence":"structured-source","population":"ALL · 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.833Z","intervention":["Prehabilitation- new form of care"],"participants":1199,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Degree of care dependency — Up to one year","Barthel Index — Up to one year","Change in NBA score — Up to one year","NBA domain change — Up to one year","Surrogate for Neurocognitive Disorder (NCD) — Up to one year","Screening tool for cognitive vulnerability — Up to one year","Dementia risk assessed by MOCA — Up to one year","Delirium — Up to one year","Frailty — Up to one year","Perioperative complications by Clavien-Dindo — Up to hospital discharge","Every mobility — Up to one year","Autonomy Preference — At the beginning of the observation","Extent of involvement in shared decision-making process — At the beginning of the observation","Arm circumference — Up to one year","Calf circumference — Up to one year","Nutritional Status — Up to one year","Change in body weight — Up to one year","Instrumental Activities of daily living (IADL) — Up to one year","Functional endurance — Up to one year","Function of the respiratory system — Up to one year"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35427","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}