{"type":"trials","record":{"id":35458,"source_id":"clinicaltrials-gov","external_id":"NCT04761458","title":"Correlation of Preoperative Global Olfactory Function With Frailty, Perioperative Neurocognitive Disorders and Mortality","brief_summary":"The aims of this research project are to evaluate whether global olfactory impairment is a reliable indicator of preoperative frailty and cognitive impairment, and whether it may predict postoperative neurocognitive disorders, morbidity and mortality in a population of older patients scheduled for elective intermediate- to high-risk elective surgery. 1. We will measure preoperative global olfactory function (threshold, discrimination, identification) and evaluate whether olfactory impairment predicts preoperative frailty (using the Edmonton Frail Scale, the Clinical Frailty Scale and handgrip strength) and postoperative complications and mortality. 2. We will address the question whether preoperative olfactory impairment may be associated with a preoperative cognitive impairment (through a neuropsychological test battery) and whether it may predict a decrease in postoperative neurocognitive function.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","enrollment":215,"countries":["Belgium"],"start_date":"2021-03-01","completion_date":"2023-12-22","last_update_date":"2025-01-15","source_url":"https://clinicaltrials.gov/study/NCT04761458","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","interventions":["Olfactory function testing","Edmonton Frail Scale","Clinical Frailty Scale","Neuropsychological test battery"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Prevalence of frailty assessed by the Edmonton Frail Scale — Preoperative period (within 3 months before surgery)","Prevalence of frailty assessed by the Clinical Frailty Scale — Preoperative period (within 3 months before surgery)","Incidence of postoperative complications — Up to 1 year postoperatively","Incidence of mortality — Up to 1 year postoperatively","Prevalence of preoperative neurocognitive disorder — Preoperative period (within 3 months before surgery)","Incidence of postoperative neurocognitive disorder — From 6 weeks to 12 weeks postoperatively"],"design_description":"NA · SINGLE GROUP · SCREENING · NONE","source_has_results":false},"controlled_terms":["Frailty","Perioperative/Postoperative Complications","Olfactory Disorder","Neurocognitive Disorders","Postoperative Cognitive Dysfunction","Olfactory function testing","Edmonton Frail Scale","Clinical Frailty Scale","Neuropsychological test battery"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct04761458","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-03-01 to 2023-12-22","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.528Z","intervention":["Olfactory function testing","Edmonton Frail Scale","Clinical Frailty Scale","Neuropsychological test battery"],"participants":215,"study_design":"NA · SINGLE GROUP · SCREENING · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Prevalence of frailty assessed by the Edmonton Frail Scale — Preoperative period (within 3 months before surgery)","Prevalence of frailty assessed by the Clinical Frailty Scale — Preoperative period (within 3 months before surgery)","Incidence of postoperative complications — Up to 1 year postoperatively","Incidence of mortality — Up to 1 year postoperatively","Prevalence of preoperative neurocognitive disorder — Preoperative period (within 3 months before surgery)","Incidence of postoperative neurocognitive disorder — From 6 weeks to 12 weeks postoperatively"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35458","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}