{"type":"trials","record":{"id":35467,"source_id":"clinicaltrials-gov","external_id":"NCT06757439","title":"Frailty and Spinal Anesthesia-Induced Hypotension in Elderly","brief_summary":"60 patients aged 65 and older with ASA I-III physical status undergoing elective surgery under spinal anesthesia will be included in the study. Patients with cardiac arrhythmia, severe heart failure, cerebrovascular disease, or contraindications to neuraxial anesthesia will be excluded. Frailty assessments will be performed using the Clinical Frailty Scale (CFS) version 2.0 by anesthesiologists in preoperative clinics or wards. Participants will be categorized into frail (CFS Level ≥4, Group I) and non-frail (CFS Level ≤3, Group II) groups. Prior to spinal anesthesia, 8 mL/kg of crystalloids will be administered. Baseline preoperative mean arterial blood pressure (MABP) and heart rate (HR) will be recorded as the average of three measurements in the supine position. During the study, MABP and HR will be monitored every 2 minutes for the first 20 minutes post-spinal anesthesia, then every 5 minutes until surgery ends. Hypotension (MABP \\<80% of baseline) will be treated with 5 mg intravenous ephedrine, while bradycardia (HR \\<50 beats/min) will be treated with 0.5 mg intravenous atropine.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Selcuk University","enrollment":60,"countries":[],"start_date":"2025-01-20","completion_date":"2025-03-20","last_update_date":"2025-01-03","source_url":"https://clinicaltrials.gov/study/NCT06757439","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"Selcuk University","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Rate of Hypotension — Preoperative baseline, every 2 minutes for the first 20 minutes, and then at 5-minute intervals u…","Rate of Bradycardia — Preoperative baseline, every 2 minutes for the first 20 minutes, and then at 5-minute intervals u…","Ephedrine usage — During the procedure","Rate of Nausea and vomiting — up to 24 hours"],"design_description":null,"source_has_results":false},"controlled_terms":["Frailty","Spinal Anesthesia"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06757439","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-01-20 to 2025-03-20","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.529Z","intervention":[],"participants":60,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Rate of Hypotension — Preoperative baseline, every 2 minutes for the first 20 minutes, and then at 5-minute intervals u…","Rate of Bradycardia — Preoperative baseline, every 2 minutes for the first 20 minutes, and then at 5-minute intervals u…","Ephedrine usage — During the procedure","Rate of Nausea and vomiting — up to 24 hours"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35467","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}