{"type":"trials","record":{"id":35478,"source_id":"clinicaltrials-gov","external_id":"NCT06731712","title":"Targeted Physical Function Exercises on Frailty and Falls Management in Pre-Frail Community-Dwelling Older Adults","brief_summary":"The investigators will conduct a randomized controlled trial to assess the impact of targeted physical function exercises on frailty and falls in community-dwelling adults over 65 years of age. Participants will be randomized to an intervention and a control group to undergo an 18-month assessment. The hypothesis of this study is to investigate the impact of targeted physical function exercises on managing frailty status and concerns about falling among pre-frail older adults. By implementing individualized intervention programs tailored to improve strength, balance, and mobility, the investigators aim to enhance physical function and reduce the risk of frailty-related adverse health outcomes. The investigators seek to empower pre-frail older adults to proactively manage their health, maintain independence, and improve their quality of life as they age.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Hellenic Mediterranean University","enrollment":121,"countries":["Greece"],"start_date":"2022-12-15","completion_date":"2024-06-15","last_update_date":"2024-12-12","source_url":"https://clinicaltrials.gov/study/NCT06731712","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:20.087268+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"Control Group","organization":"Hellenic Mediterranean University","interventions":["Physical Function Exercises"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Level of Frailty status — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18…","Concerns about Falling — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18…","Physical Performance — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18 mo…","Functional Mobility — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18 mon…","Functional Balance — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18 mont…","Quality of Daily Living — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18…","Depression — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18 months (T3)."],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · NONE","source_has_results":false},"controlled_terms":["Frailty Syndrome","Pre-frail Older Adults","Physical Function Exercises"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06731712","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-12-15 to 2024-06-15","comparator":"Control Group","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.531Z","intervention":["Physical Function Exercises"],"participants":121,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Level of Frailty status — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18…","Concerns about Falling — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18…","Physical Performance — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18 mo…","Functional Mobility — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18 mon…","Functional Balance — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18 mont…","Quality of Daily Living — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18…","Depression — From baseline (T0), at 6 months (T1), at 12 months (T2), to the end of the intervention at 18 months (T3)."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35478","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}