{"type":"trials","record":{"id":35652,"source_id":"clinicaltrials-gov","external_id":"NCT07668180","title":"A Study to Evaluate the Efficacy and Safety of IN-207907 Injection in Elderly Patients With Sarcopenia","brief_summary":"The goal of this clinical trial is to learn if intervention can treat sarcopenia in the elderly. Researchers will compare IN-207907 120 mg, 240 mg, 360 mg and placebo to see if SPPB score improves.","overall_status":"Not Yet Recruiting","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"HK inno.N Corporation","enrollment":100,"countries":[],"start_date":"2026-09-01","completion_date":"2028-02-01","last_update_date":"2026-06-25","source_url":"https://clinicaltrials.gov/study/NCT07668180","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"Placebo","organization":"HK inno.N Corporation","interventions":["IN-207907 120 mg","IN-207907 240 mg","IN-207907 360 mg","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in the Short Physical Performance Battery (SPPB) total score — From baseline to week 12","Change in the Short Physical Performance Battery (SPPB) total score — From baseline to week 4 and 8","Change in time to complete the 4-Meter Walk Test (4MWT) — From baseline to week 4, 8 and 12","Change in time to complete the 5 Times Chair Stand Test — From baseline to week 4, 8 and 12","Change in time to complete the Timed Up and Go (TUG) test — From baseline to week 4, 8 and 12","Change in handgrip strength measured using a digital hand dynamometer — From baseline to week 4, 8 and 12","Change in Appendicular Skeletal muscle Mass (ASM) as measured by Dual-energy X-ray Absorptiometry (DEXA) — From baselin…","Change in the total score of the Strength, Assistance with walking, Rise from a chair, Climb stairs, and Falls (SARC-F)…","Change in the total score of the Sarcopenia Quality of Life (SarQoL) questionnaire — From baseline to week 12","Change in proportion of FoxP3+ regulatory T cells — From baseline to week 4, 8 and 12","Change in serum interleukin-6 (IL-6) concentration — From baseline to week 4, 8 and 12","Change in serum insulin-like growth factor-1 (IGF-1) concentration — From baseline to week 4, 8 and 12","Change in high-sensitivity C-reactive protein (hs-CRP) level — From baseline to week 4, 8 and 12","Exercise and dietary compliance rate — From baseline to week 4, 8 and 12"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":false},"controlled_terms":["Sarcopenia in Elderly","IN-207907 120 mg","IN-207907 240 mg","IN-207907 360 mg","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07668180","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-09-01 to 2028-02-01","comparator":"Placebo","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.772Z","intervention":["IN-207907 120 mg","IN-207907 240 mg","IN-207907 360 mg","Placebo"],"participants":100,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in the Short Physical Performance Battery (SPPB) total score — From baseline to week 12","Change in the Short Physical Performance Battery (SPPB) total score — From baseline to week 4 and 8","Change in time to complete the 4-Meter Walk Test (4MWT) — From baseline to week 4, 8 and 12","Change in time to complete the 5 Times Chair Stand Test — From baseline to week 4, 8 and 12","Change in time to complete the Timed Up and Go (TUG) test — From baseline to week 4, 8 and 12","Change in handgrip strength measured using a digital hand dynamometer — From baseline to week 4, 8 and 12","Change in Appendicular Skeletal muscle Mass (ASM) as measured by Dual-energy X-ray Absorptiometry (DEXA) — From baselin…","Change in the total score of the Strength, Assistance with walking, Rise from a chair, Climb stairs, and Falls (SARC-F)…","Change in the total score of the Sarcopenia Quality of Life (SarQoL) questionnaire — From baseline to week 12","Change in proportion of FoxP3+ regulatory T cells — From baseline to week 4, 8 and 12","Change in serum interleukin-6 (IL-6) concentration — From baseline to week 4, 8 and 12","Change in serum insulin-like growth factor-1 (IGF-1) concentration — From baseline to week 4, 8 and 12","Change in high-sensitivity C-reactive protein (hs-CRP) level — From baseline to week 4, 8 and 12","Exercise and dietary compliance rate — From baseline to week 4, 8 and 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35652","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}