{"type":"trials","record":{"id":35792,"source_id":"clinicaltrials-gov","external_id":"NCT05688956","title":"Protein Supplement and Exercise Training for the Treatment of Sarcopenia Risk in Older Adults","brief_summary":"To explore the effectiveness of a 12-week resistance exercise programme plus or minus an oral nutritional supplement on the nutritional status of community-dwelling older adults who receive home care and are at risk of sarcopenia.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University College Dublin","enrollment":46,"countries":["Ireland"],"start_date":"2023-02-01","completion_date":"2025-05-31","last_update_date":"2026-03-17","source_url":"https://clinicaltrials.gov/study/NCT05688956","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":"POWER","age_range":"70 Years to 100 Years","comparator":"(ii) Exercise-alone group","organization":"University College Dublin","interventions":["Fortimel Advanced, Nutricia","Resistance Exercise programme","Dietary advice"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change from baseline functional status at 12 weeks — 12 weeks","Change from baseline nutritional status at 12 weeks — 12 weeks","Adherence — 12 weeks","Muscle mass — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Muscle strength — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Five Times Sit-To-Stand test — Values at baseline will be compared to values recorded at 12 and at 24 weeks","4 m Gait Speed test — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Change in self-reported quality of life — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Change in risk of depression — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Change in functional status — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Change in baseline nutritional status at week 24 — 24 weeks","Change from baseline functional status at 24 weeks — 24 weeks","Retention — Up to 24 weeks","Recruitment — Up to 24 weeks"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Sarcopenia","Fortimel Advanced, Nutricia","Resistance Exercise programme","Dietary advice"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct05688956","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-02-01 to 2025-05-31","comparator":"(ii) Exercise-alone group","confidence":"structured-source","population":"ALL · 70 Years to 100 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.794Z","intervention":["Fortimel Advanced, Nutricia","Resistance Exercise programme","Dietary advice"],"participants":46,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change from baseline functional status at 12 weeks — 12 weeks","Change from baseline nutritional status at 12 weeks — 12 weeks","Adherence — 12 weeks","Muscle mass — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Muscle strength — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Five Times Sit-To-Stand test — Values at baseline will be compared to values recorded at 12 and at 24 weeks","4 m Gait Speed test — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Change in self-reported quality of life — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Change in risk of depression — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Change in functional status — Values at baseline will be compared to values recorded at 12 and at 24 weeks","Change in baseline nutritional status at week 24 — 24 weeks","Change from baseline functional status at 24 weeks — 24 weeks","Retention — Up to 24 weeks","Recruitment — Up to 24 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35792","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}