{"type":"trials","record":{"id":35826,"source_id":"clinicaltrials-gov","external_id":"NCT06689618","title":"Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults","brief_summary":"During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on motoneuronal activation in healthy adults, which typically decreases with age. The investigators will also test whether WB-EMS Exercise will improve measures of physical function. Participants will undergo clinical and electrophysiologic testing before and after the WB-EMS Exercise intervention. The WB-EMS Exercise intervention will be delivered two times per week for four weeks. The hypothesis is that whole-body electrical muscle stimulation combined with physical exercise (WB-EMS Exercise) could bypass the problem of insufficient motoneuronal activation to improve exercise effect in older adults.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Missouri-Columbia","enrollment":12,"countries":["United States"],"start_date":"2025-08-18","completion_date":"2026-06-01","last_update_date":"2026-02-17","source_url":"https://clinicaltrials.gov/study/NCT06689618","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":null,"organization":"University of Missouri-Columbia","interventions":["Exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Mean change from baseline in motor unit firing rates of the vastus lateralis using decomposition electromyography (dEMG…","Mean change from baseline in central activation ratio of the vastus lateralis using interpolated twitch technique (ITT)…","Mean change from baseline in mobility testing — Measured within 3 days of starting the intervention and within 3 days o…","Mean change from baseline in balance testing — Measured within 3 days of starting the intervention and within 3 days of…","Treatment Feedback Questionnaire — Measured within 3 days of completing the intervention"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Aging","Sarcopenia","Sarcopenia in Elderly","Exercise"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct06689618","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-08-18 to 2026-06-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.800Z","intervention":["Exercise"],"participants":12,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Mean change from baseline in motor unit firing rates of the vastus lateralis using decomposition electromyography (dEMG…","Mean change from baseline in central activation ratio of the vastus lateralis using interpolated twitch technique (ITT)…","Mean change from baseline in mobility testing — Measured within 3 days of starting the intervention and within 3 days o…","Mean change from baseline in balance testing — Measured within 3 days of starting the intervention and within 3 days of…","Treatment Feedback Questionnaire — Measured within 3 days of completing the intervention"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35826","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}