{"type":"trials","record":{"id":35889,"source_id":"clinicaltrials-gov","external_id":"NCT06499012","title":"The Efficacy of Nutrilite All-plant Protein Booster to Improve Sarcopenia and Osteoarthritis in Middle-aged and Elderly People","brief_summary":"The goal of this clinical trial is to learn whether Amway Nutrilite All-plant protein booster prototype product (test product) will improve sarcopenia (SA) and osteoarthritis (OA) in middle-aged and elderly people. It will also learn about the improvement of Quality of life (QoL) in them. The main questions it aims to answer are: * Does the test product will improve the SA in terms of Short Physical Performance Battery (SPPB score) after 12 weeks' intervention? * Does the test product will improve the OA in terms of Western Ontario and McMaster Universities Arthritis (WOMAC Index) after 12 weeks' intervention? Researchers will compare Amway All-plant protein booster prototype product to a placebo (a look-alike substance that contains no similar active nutrient ingredients) to see if the test product works to improve SA and OA. Participants will: * Take the test product or a placebo 2 spoons (15g) twice per day for 12 weeks * Visit the site on the baseline day and the 84th day (end day of 12 weeks) for checkups and tests","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Amway (China) R&D Center","enrollment":139,"countries":["China"],"start_date":"2025-07-08","completion_date":"2025-10-02","last_update_date":"2025-11-24","source_url":"https://clinicaltrials.gov/study/NCT06499012","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years to 70 Years","comparator":"All-plant Protein Booster Product Group; Placebo Group","organization":"Amway (China) R&D Center","interventions":["All-plant Protein Booster Product Group","Placebo Group"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change of SPPB Score from baseline — baseline day 0, week 12","Change of WOMAC 3.1 index from baseline — baseline day 0, week 12","Change of bone density measured by DXA Bone Densitometer from baseline — baseline day 0, week 12","Improvement of Fat and Muscle Portions measured by Inbody S10 from baseline — baseline day 0, week 12","Improvement of Quality of Life by WHOQOL BREF — baseline day 0, week 12","Improvement of Quality of Life by SF-36 — baseline day 0, week 12","Improvement of Quality of Life by Chalder Fatigue Scale (CFQ 11) — baseline day 0, week 12","Change of SFQ from baseline — baseline day 0, week 12"],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · DOUBLE","source_has_results":false},"controlled_terms":["Osteoarthritis","Sarcopenia","All-plant Protein Booster Product Group","Placebo Group"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct06499012","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-07-08 to 2025-10-02","comparator":"All-plant Protein Booster Product Group; Placebo Group","confidence":"structured-source","population":"ALL · 50 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.809Z","intervention":["All-plant Protein Booster Product Group","Placebo Group"],"participants":139,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change of SPPB Score from baseline — baseline day 0, week 12","Change of WOMAC 3.1 index from baseline — baseline day 0, week 12","Change of bone density measured by DXA Bone Densitometer from baseline — baseline day 0, week 12","Improvement of Fat and Muscle Portions measured by Inbody S10 from baseline — baseline day 0, week 12","Improvement of Quality of Life by WHOQOL BREF — baseline day 0, week 12","Improvement of Quality of Life by SF-36 — baseline day 0, week 12","Improvement of Quality of Life by Chalder Fatigue Scale (CFQ 11) — baseline day 0, week 12","Change of SFQ from baseline — baseline day 0, week 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"joint-cartilage-aging","is_published":true,"match_reasons":["Title contains controlled term: osteoarthritis.","Abstract contains controlled term: osteoarthritis.","Source terminology contains: osteoarthritis.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Joint and cartilage ageing","slug":"joint-cartilage-aging"}},{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35889","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}