{"type":"trials","record":{"id":359,"source_id":"clinicaltrials-gov","external_id":"NCT07799402","title":"Microbiome in Aging of Gut and Brain","brief_summary":"The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline. The study includes young healthy adults, cognitively healthy older adults, older adults with mild cognitive impairment (MCI), and older adults with Alzheimer's disease or related dementia. At the baseline visit, participants complete assessments of medical history, cognitive function, physical function, and diet and provide biological samples that may include stool, saliva, oral swabs, blood, and urine. Researchers will study the gut and oral microbiome and related biological factors, including metabolites and markers of intestinal permeability and inflammation, to determine whether these measures differ according to cognitive status. Young healthy adults, cognitively healthy older adults, and participants with MCI will be followed annually for up to 5 years to evaluate changes in the microbiome and cognitive function over time. Participants with Alzheimer's disease or related dementia will participate in the baseline assessment only. No drug, treatment, or other research intervention is assigned as part of this study.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of South Florida","enrollment":700,"countries":["United States"],"start_date":"2021-09-16","completion_date":"2031-09-01","last_update_date":"2026-09-21","source_url":"https://clinicaltrials.gov/study/NCT07799402","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:03.776617+00:00","last_seen_at":"2026-09-25T06:05:41.111+00:00","metadata":{"sex":"ALL","acronym":"MiaGB","age_range":"18 Years","comparator":null,"organization":"University of South Florida","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Gut Microbiome Shannon Diversity Index — Baseline for all participants and annually for up to 5 years for longitudinall…","Montreal Cognitive Assessment (MoCA) Score — Baseline for all participants and annually for up to 5 years for longitudi…"],"design_description":null,"source_has_results":false},"controlled_terms":["Mild Cognitive Impairment","Alzheimer Disease (AD)","Dementia"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: microbiome.","quality_checked_at":"2026-09-25T06:05:45.671606+00:00","duplicate_cluster_key":"id:nct07799402","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-09-16 to 2031-09-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:41.112Z","intervention":[],"participants":700,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Gut Microbiome Shannon Diversity Index — Baseline for all participants and annually for up to 5 years for longitudinall…","Montreal Cognitive Assessment (MoCA) Score — Baseline for all participants and annually for up to 5 years for longitudi…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"microbiome-dysbiosis","is_published":true,"match_reasons":["Title contains controlled term: microbiome.","Abstract contains controlled term: microbiome.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Microbiome and dysbiosis","slug":"microbiome-dysbiosis"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/359","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}