{"type":"trials","record":{"id":35901,"source_id":"clinicaltrials-gov","external_id":"NCT07205510","title":"Sarcopenia, Metabolic Diseases, and Integrated Aging Longitudinal Evaluation (SMILE)","brief_summary":"This study aims to establish an ambispective cohort platform centered on the pathological axis of \"sarcopenia-metabolic disorders-aging progression\", integrating multimodal data including demographic characteristics, lifestyle factors, clinical phenotypes, laboratory tests, medical imaging, and biospecimens. Namely 'Sarcopenia, Metabolic Diseases, and Integrated Aging Longitudinal Evaluation (SMILE)'.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"RenJi Hospital","enrollment":10000,"countries":["China"],"start_date":"2020-12-01","completion_date":"2040-12-31","last_update_date":"2025-10-03","source_url":"https://clinicaltrials.gov/study/NCT07205510","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":null,"organization":"RenJi Hospital","interventions":["nothing"],"registry_source":"ClinicalTrials.gov","outcome_measures":["all-cause mortality — From enrollment to the 5-year and 10-year follow-up visit.","cause-specific mortality — At 5 and 10 years from the baseline visit.","Major adverse cardiovascular events — At 5 and 10 years from the baseline visit."],"design_description":null,"source_has_results":false},"controlled_terms":["Sarcopenia","Metabolic Diseases","All-cause Mortality","Aging","Cardiometabolic Diseases","nothing"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07205510","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-12-01 to 2040-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.810Z","intervention":["nothing"],"participants":10000,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["all-cause mortality — From enrollment to the 5-year and 10-year follow-up visit.","cause-specific mortality — At 5 and 10 years from the baseline visit.","Major adverse cardiovascular events — At 5 and 10 years from the baseline visit."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35901","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}