{"type":"trials","record":{"id":35949,"source_id":"clinicaltrials-gov","external_id":"NCT05790863","title":"Effects of Low-volume HIIT Versus MICT on Physical Performance in Older Adults With Possible Sarcopenia","brief_summary":"Background: Sarcopenia is an age-related geriatric syndrome characterized by progressive loss of muscle mass and function. Before the diagnosis of sarcopenia, a \"possible sarcopenia\" stage has been proposed recently, characterized by low muscle strength or poor physical performance, even with normal muscle mass. The definition of \"possible sarcopenia\" emphasizes the importance of early intervention. Due to the lack of effective pharmaceutical treatments, exercise is recommended as the most available intervention for sarcopenia. High-intensity interval training (HIIT), a time-efficient aerobic training, has gained increasing popularity for its benefits in physiologic outcomes such as muscle strength and physical functions in other populations. However, the benefits of HIIT have not been well-studied following older adults with possible sarcopenia. In the present study, we aim to investigate the effects of a 7-week HIIT and moderate-intensity continuous aerobic training (MICT) on physical performance in older individuals with possible sarcopenia. We hypothesize that HIIT will confer physical benefits over MICT (i.e., traditional endurance exercise) and will be generally well-tolerated in older adults. Method: The participants will be randomly allocated into the HIIT or MICT group (1:1 ratio). The participants will receive the training 3 times per week over seven weeks. HIIT consists of 5 bouts of interval training intensity with 1-minute-high intensity (76-90% HRmax) and 1-minute recovery per session (total 15 minutes with warm-up and cool-down). MICT will adopt an intensity of 65-70% HRmax training that lasts less than 30 minutes per session (total 25 minutes with warm-up and cool-down). Evaluation will be performed at baseline, after 4 weeks, and 7 weeks of the intervention. The primary outcomes include 10-meter walking test and the five-time chair stand test. The secondary outcomes include grip strength, the functional stretch test; the Exercise Enjoyment Scale and the Physical Activity Enjoyment Scale for affective valence. Discussion: This is the first study to investigate the effects of low-volume HIIT on physical performance and affective valence in older adults with possible sarcopenia. This study will provide critical evidence to guide early prevention and intervention of exercise regimens for possible sarcopenia.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"The Hong Kong Polytechnic University","enrollment":30,"countries":["China"],"start_date":"2023-03-07","completion_date":"2024-10-30","last_update_date":"2025-07-22","source_url":"https://clinicaltrials.gov/study/NCT05790863","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Moderate-intensity continuous training group","organization":"The Hong Kong Polytechnic University","interventions":["Ergometer cycling"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change from Baseline in time of the The 5 repeated sit-to-stand test after 7 weeks of intervention — Baseline and after…","Change from Baseline in walking speed of the 10 meter-walk test after 7 weeks of intervention — Baseline and after 7 we…","Change from Baseline in Hand grip strength after 7 weeks of intervention — Baseline and after 7 weeks of intervention","Change from Baseline in distance of The functional stretch test after 7 weeks of intervention — Baseline and after 7 we…","Change from Baseline in score of The Exercise Enjoyment Scale after 7 weeks of intervention — Baseline and after 7 week…","Change from Baseline in score of The Physical activity enjoyment scale after 7 weeks of intervention — Baseline and aft…"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Sarcopenia","Ergometer cycling"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct05790863","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-03-07 to 2024-10-30","comparator":"Moderate-intensity continuous training group","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.818Z","intervention":["Ergometer cycling"],"participants":30,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change from Baseline in time of the The 5 repeated sit-to-stand test after 7 weeks of intervention — Baseline and after…","Change from Baseline in walking speed of the 10 meter-walk test after 7 weeks of intervention — Baseline and after 7 we…","Change from Baseline in Hand grip strength after 7 weeks of intervention — Baseline and after 7 weeks of intervention","Change from Baseline in distance of The functional stretch test after 7 weeks of intervention — Baseline and after 7 we…","Change from Baseline in score of The Exercise Enjoyment Scale after 7 weeks of intervention — Baseline and after 7 week…","Change from Baseline in score of The Physical activity enjoyment scale after 7 weeks of intervention — Baseline and aft…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35949","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}