{"type":"trials","record":{"id":35962,"source_id":"clinicaltrials-gov","external_id":"NCT07046130","title":"Reduction in Resistance Training Volume and Neuromuscular Adaptations in Older Adults","brief_summary":"The goal of this clinical trial is to evaluate how reducing resistance training volume affects neuromuscular adaptations in older adults aged 60 to 70 years. The main questions it aims to answer are: Can strength and muscle adaptations be maintained with lower training volume? Does reducing training volume influence muscle power and hypertrophy in older adults? Researchers will compare two groups: A group that reduces training volume in one or both legs A group that maintains the same training volume in both legs to see if reducing volume leads to different neuromuscular outcomes. Participants will: Complete an initial 10-week strength training program (2x/week) using unilateral leg press and knee extension machines, performing 3 sets per exercise Undergo tests for muscle strength (1-RM), muscle thickness (ultrasound), and power (isokinetic dynamometry) at weeks 0, 5, and 10 After 10 weeks, be randomly assigned to: A reduced-volume group: one leg does 2 sets and the other 1 set per exercise Or a control group: both legs continue doing 3 sets Continue training for another 10 weeks under the assigned protocol Repeat strength, muscle thickness, and power assessments at weeks 5 and 10 of phase 2 Attend a dietary intake interview with a registered dietitian This study will help determine the minimum effective training volume needed to maintain strength and muscle health in older adults, potentially improving long-term adherence to exercise programs.","overall_status":"Enrolling By Invitation","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Sao Paulo","enrollment":45,"countries":["Brazil"],"start_date":"2025-05-29","completion_date":"2026-12-18","last_update_date":"2025-07-01","source_url":"https://clinicaltrials.gov/study/NCT07046130","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Enrolling By Invitation. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years to 70 Years","comparator":"Maintained Volume - 3 Sets (MV3SETS)","organization":"University of Sao Paulo","interventions":["Resistance Training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Maximum Dynamic Strength (1-RM) in Knee Extension and Leg Press (kg) — Up to end of study data collection (both stages)…","Muscle Thickness (cm) - Quadriceps Muscle Group (Ultrasound) — Up to end of study data collection (both stages), i.e.,…","Thigh Fat-Free Mass (kg) - Dual-Energy X-ray Absorptiometry (DXA) — Up to end of study data collection (both stages), i…","Average Power (Watts) - Isokinetic Knee Extension Test — Up to end of study data collection (both stages), i.e., assess…"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","source_has_results":false},"controlled_terms":["Sarcopenia in Elderly","Dynapenia","Resistance Training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07046130","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-05-29 to 2026-12-18","comparator":"Maintained Volume - 3 Sets (MV3SETS)","confidence":"structured-source","population":"ALL · 60 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.820Z","intervention":["Resistance Training"],"participants":45,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Maximum Dynamic Strength (1-RM) in Knee Extension and Leg Press (kg) — Up to end of study data collection (both stages)…","Muscle Thickness (cm) - Quadriceps Muscle Group (Ultrasound) — Up to end of study data collection (both stages), i.e.,…","Thigh Fat-Free Mass (kg) - Dual-Energy X-ray Absorptiometry (DXA) — Up to end of study data collection (both stages), i…","Average Power (Watts) - Isokinetic Knee Extension Test — Up to end of study data collection (both stages), i.e., assess…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training, strength training.","Source terminology contains: resistance training.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/35962","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}