{"type":"trials","record":{"id":36002,"source_id":"clinicaltrials-gov","external_id":"NCT05458258","title":"Studying Malnutrition And Sarcopenia In Older Adults With Acute Myeloid Leukemia","brief_summary":"This study will explore how malnutrition (poor nutrition/diet) and sarcopenia (a condition that causes a loss of muscle and bone mass) affects study participants over the age of 60 with acute myeloid leukemia (AML) who will receive induction chemotherapy (chemotherapy given as the first treatment to help cancer go into remission) and/or cancer drugs as part of standard care for AML. By studying how these nutritional and skeletal factors, doctors leading this study hope to learn how malnutrition and sarcopenia may be able to predict certain outcomes --such as how long study participants with poor nutrition and muscle loss can live after chemotherapy- for older (age 60+) individuals with AML.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Chicago","enrollment":239,"countries":["United States"],"start_date":"2023-03-01","completion_date":"2025-04-18","last_update_date":"2025-04-30","source_url":"https://clinicaltrials.gov/study/NCT05458258","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":null,"organization":"University of Chicago","interventions":["Bioelectrical Impedence Analysis Device","6 Minute Walk Test","Computed Tomography Scans to Measure Skeletal Muscular Index","Blood Test/Blood Draw","Hand Grip Strength Test"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Treatment-Related Mortality Rates Based on Incidence of Sarcopenia in All Study Participants — 60 days","The prognostic impact of malnutrition and sarcopenia on treatment-related mortality rates and overall survival in study…","Incidence of Malnutrition Among Participants in Group 1 Compared to Incidence of Malnutrition in Healthy Control Group…","Incidence of Sarcopenia Among Participants in Group 1 Compared to Incidence of Sarcopenia in Healthy Control Group — 60…"],"design_description":null,"source_has_results":false},"controlled_terms":["Acute Myeloid Leukemia","Leukemia, Myeloid","Bioelectrical Impedence Analysis Device","6 Minute Walk Test","Computed Tomography Scans to Measure Skeletal Muscular Index","Blood Test/Blood Draw","Hand Grip Strength Test"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct05458258","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-03-01 to 2025-04-18","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.825Z","intervention":["Bioelectrical Impedence Analysis Device","6 Minute Walk Test","Computed Tomography Scans to Measure Skeletal Muscular Index","Blood Test/Blood Draw","Hand Grip Strength Test"],"participants":239,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Treatment-Related Mortality Rates Based on Incidence of Sarcopenia in All Study Participants — 60 days","The prognostic impact of malnutrition and sarcopenia on treatment-related mortality rates and overall survival in study…","Incidence of Malnutrition Among Participants in Group 1 Compared to Incidence of Malnutrition in Healthy Control Group…","Incidence of Sarcopenia Among Participants in Group 1 Compared to Incidence of Sarcopenia in Healthy Control Group — 60…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Title supplies longevity context: older adult.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36002","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}