{"type":"trials","record":{"id":36030,"source_id":"clinicaltrials-gov","external_id":"NCT05798169","title":"Impact of Acute Hospitalisation and Resistance Training on Muscle Architecture and Physical Performance in Older Adults","brief_summary":"Sarcopenia characterised by loss of muscle mass, muscle strength and physical performance burdens many older adults since the condition is related to functional decline. Periods of inactivity such as during hospitalisation leads to further functional decline. It has been reported that the loss of muscle mass associated with sarcopenia not only entails a decrease in muscle mass but also changes in muscle architecture. Knowledge on changes in muscle architecture is essential since it is one of the most important determinants on muscle strength and thus physical performance. The main objective of this study is to investigate changes in muscle architecture and physical performance during acute hospitalisation and after discharge in older adults and subsequently the effectiveness of resistance training of the lower limb during acute hospitalisation. If successful, our study could have a great impact on the individual, as well as societal level, due to a better understanding of the factors related to sarcopenia and the prevention of functional decline as a result of hospitalisation.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Odense University Hospital","enrollment":274,"countries":["Denmark"],"start_date":"2023-01-05","completion_date":"2024-12-20","last_update_date":"2025-03-27","source_url":"https://clinicaltrials.gov/study/NCT05798169","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"Odense University Hospital","interventions":["Resistance training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change from baseline B-mode ultrasonography — Baseline (day of hospitalisation) to day of discharge from hospital (an a…","Change from baseline 4 meter Gait Speed Test — Baseline (Day of hospitalisation) to day of discharge from hospital (an…","Change from baseline B-mode ultrasonography — Change from baseline (day of hospitalisation) to 1-month follow-up and 3-…","Change from baseline 4 meter Gait Speed Test — Change from baseline (day of hospitalisation) to 1-month follow-up and 3…","Change from baseline 30s Chair Stand test — Baseline (day of hospitalisation) to day of discharge from hospital (an ave…","Change from baseline Barthel-Index 100 (Shahs version) — Baseline (day of hospitalisation) to day of discharge from hos…","Change from baseline Bioimpedance — Baseline (day of hospitalisation) to day of discharge from hospital (an average of…","Length of hospital stay — Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week)","Mortality — Baseline (day of hospitalization) to 3-months follow-up","Unplanned hospitalisation — Day of discharge from hospital to 3-months follow-up","Individual level of physiotherapy — Baseline (day of hospitalisation) to 3-months follow-up"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":false},"controlled_terms":["Sarcopenia","Functional Decline","Muscle Architecture","Gait Speed","Ultrasound","Physical Performance","Resistance Training","Hospitalisation","Acutely Ill","Older Adults","Resistance training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct05798169","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-01-05 to 2024-12-20","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.829Z","intervention":["Resistance training"],"participants":274,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change from baseline B-mode ultrasonography — Baseline (day of hospitalisation) to day of discharge from hospital (an a…","Change from baseline 4 meter Gait Speed Test — Baseline (Day of hospitalisation) to day of discharge from hospital (an…","Change from baseline B-mode ultrasonography — Change from baseline (day of hospitalisation) to 1-month follow-up and 3-…","Change from baseline 4 meter Gait Speed Test — Change from baseline (day of hospitalisation) to 1-month follow-up and 3…","Change from baseline 30s Chair Stand test — Baseline (day of hospitalisation) to day of discharge from hospital (an ave…","Change from baseline Barthel-Index 100 (Shahs version) — Baseline (day of hospitalisation) to day of discharge from hos…","Change from baseline Bioimpedance — Baseline (day of hospitalisation) to day of discharge from hospital (an average of…","Length of hospital stay — Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week)","Mortality — Baseline (day of hospitalization) to 3-months follow-up","Unplanned hospitalisation — Day of discharge from hospital to 3-months follow-up","Individual level of physiotherapy — Baseline (day of hospitalisation) to 3-months follow-up"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Source terminology contains: resistance training.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36030","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}