{"type":"trials","record":{"id":36130,"source_id":"clinicaltrials-gov","external_id":"NCT03362801","title":"SArcopenia, Mobility, PHYsical Activity and Post-operative Risk of Bladder Carcinoma in the Elderly","brief_summary":"Sarcopenia is associated with lower prognosis in solid tumors, but this has not been studied in bladder carcinoma requiring cystectomy. According to EWGSOP recommendations, the diagnosis of sarcopenia is based on walking speed, grip strength and muscle mass. These three elements can easily be measured (specially muscle mass measurement by bioimpedencemetry or tomodensitometry). This cohort study will collect clinical complementary elements to better understand the associated factors present with sarcopenia, in order to prepare an interventional preoperative physical reconditioning study. The mobility measurement will be carried out by the QAPPA questionnaire (validated in French in the elderly) and the quantitative measurement of activity and rest hours during a week by a wrist actimeter. Standardized geriatric data will also be collected: ADL, IADL for autonomy, MMSE for cognitive status, nutritional status (% weight loss, BMI), pain, GDS15 for depression screening, updated Charlson Comorbidity Index to identify polypathology and The STOPP tool for potentially inappropriate medication. Post-operative morbidity mortality at 30 days will be evaluated according to Clavien-Dindo classification. Investigators will also evaluate 6 months geriatric complications : falls, loss of autonomy and decreased mobility and physical activity, cognitive degradation, undernutrition, institutionalization","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University Hospital, Caen","enrollment":69,"countries":["France"],"start_date":"2017-10-30","completion_date":"2026-02-01","last_update_date":"2024-07-19","source_url":"https://clinicaltrials.gov/study/NCT03362801","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":"SAMPHYR","age_range":"65 Years","comparator":null,"organization":"University Hospital, Caen","interventions":["sarcopenia and mobility measurement"],"registry_source":"ClinicalTrials.gov","outcome_measures":["post-operative morbidity — at 30 days","post-operative mortality — at 30 days","post-operative complications — 8 months","impedancemetric value — 2 months","sarcopenic status — between baseline; preoperative and at 6 months post-operative","quality of life scores — preoperative and 6-month post-operative"],"design_description":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","source_has_results":false},"controlled_terms":["Sarcopenia","Bladder Cancer","sarcopenia and mobility measurement"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct03362801","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-10-30 to 2026-02-01","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.844Z","intervention":["sarcopenia and mobility measurement"],"participants":69,"study_design":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["post-operative morbidity — at 30 days","post-operative mortality — at 30 days","post-operative complications — 8 months","impedancemetric value — 2 months","sarcopenic status — between baseline; preoperative and at 6 months post-operative","quality of life scores — preoperative and 6-month post-operative"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36130","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}