{"type":"trials","record":{"id":36241,"source_id":"clinicaltrials-gov","external_id":"NCT04999488","title":"Impact of Orally Administered BPM31510 on Mitochondrial Energetics in Older Adults With Sarcopenia","brief_summary":"This study is being done to gather data on whether oral supplementation of CoQ10 is enriched in the blood and muscles in older adults with sarcopenia. This study involves 28 consecutive days of oral CoQ10 supplementation to explore changes in muscle strength, aerobic capacity and physical function with CoQ10 supplementation.","overall_status":"Withdrawn","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"AdventHealth Translational Research Institute","enrollment":0,"countries":["United States"],"start_date":"2023-12-01","completion_date":"2024-12-01","last_update_date":"2023-07-24","source_url":"https://clinicaltrials.gov/study/NCT04999488","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":"COQ10","age_range":"65 Years to 90 Years","comparator":"Older adults with sarcopenia (placebo); Older adults with sarcopenia (drug)","organization":"AdventHealth Translational Research Institute","interventions":["BPM31510","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Measurement of skeletal muscle — Following 28 days of treatment","Measurement of platelet CoQ10 level — Following 28 days of treatment"],"design_description":"RANDOMIZED · SINGLE GROUP · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Sarcopenia","BPM31510","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct04999488","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-12-01 to 2024-12-01","comparator":"Older adults with sarcopenia (placebo); Older adults with sarcopenia (drug)","confidence":"structured-source","population":"ALL · 65 Years to 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.859Z","intervention":["BPM31510","Placebo"],"participants":0,"study_design":"RANDOMIZED · SINGLE GROUP · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"EARLY_PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Measurement of skeletal muscle — Following 28 days of treatment","Measurement of platelet CoQ10 level — Following 28 days of treatment"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36241","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}