{"type":"trials","record":{"id":36450,"source_id":"clinicaltrials-gov","external_id":"NCT03724461","title":"Effects of Resistance Training With High vs. Light-moderate Loads on Muscle-tendon Function in the Elderly","brief_summary":"There are no unbiased studies that have analyzed the effects of resistance training with traditional, heavy versus light-moderate loads on muscle, tendon and bone in elderly people. The purpose of the present study is to assess the effects on muscle mass and function, tendon and bone of two different training intensities, light-moderate vs. heavy load, in people older than 65 years old. The study will be carried out with a randomized controlled design. Participants will perform single training sessions and a 12-wk dynamic resistance training program on the knee extensors with different training intensities on each leg. One leg will train with heavy loads and the other one will train with light-moderate loads, but matching the load x repetitions performed by the contralateral side.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Castilla-La Mancha","enrollment":55,"countries":["Spain"],"start_date":"2017-09-01","completion_date":"2020-03-12","last_update_date":"2020-06-16","source_url":"https://clinicaltrials.gov/study/NCT03724461","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:24.196666+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"High intensity vs Control (12 weeks); Light intensity vs Control (12 weeks)","organization":"University of Castilla-La Mancha","interventions":["High Intensity resistance training (12 weeks)","Light-moderate intensity resistance training (12 weeks)","Control (12 weeks)","One High Intensity resistance training session","One Light-moderate intensity resistance training session"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Acute change in muscle size (cross sectional area, cm2) — Change from baseline at 5 minutes after a training session","Change in muscle size (cross sectional area, cm2) — Change from baseline to week 12","Acute change in muscle function (N) — Change from baseline at 5 minutes after a training session","Change in muscle function (N) — Change from baseline to week 12","Change in patellar tendon stiffness (N/mm) — Change from baseline to week 12","Acute change in patellar tendon stiffness (N/mm) — Change from baseline at 5 minutes after a training session","Change in muscle mass (kg) — Change from baseline to week 12","Change in bone mass (g) — Change from baseline to week 12","Acute change in muscle excitation (mV) — Change from baseline at 5 minutes after a training session","Change in muscle excitation (mV) — Change from baseline to week 12","Change in physical function — Change from baseline to week 12","Blood analysis: Acute change in oxidative stress — Change from baseline at 5 minutes after a training session","Blood analysis: Change in oxidative stress — Change from baseline to week 12","Blood analysis: Acute change in Inflammation — Change from baseline at 5 minutes after a training session (Acute)","Blood analysis: Change in inflammation — Change from baseline to week 12","Blood analysis: Acute change in anabolic processes — Change from baseline at 5 minutes after a training session","Blood analysis: Change in anabolic processes — Change from baseline to week 12","Blood analysis: Acute change in catabolic processes — Change from baseline at 5 minutes after a training session","Blood analysis: Change in catabolic processes — Change from baseline to week 12"],"design_description":"RANDOMIZED · FACTORIAL · PREVENTION · SINGLE","source_has_results":false},"controlled_terms":["Aging","Sarcopenia","Frail Elderly Syndrome","High Intensity resistance training (12 weeks)","Light-moderate intensity resistance training (12 weeks)","Control (12 weeks)","One High Intensity resistance training session","One Light-moderate intensity resistance training session"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct03724461","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-09-01 to 2020-03-12","comparator":"High intensity vs Control (12 weeks); Light intensity vs Control (12 weeks)","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.477Z","intervention":["High Intensity resistance training (12 weeks)","Light-moderate intensity resistance training (12 weeks)","Control (12 weeks)","One High Intensity resistance training session","One Light-moderate intensity resistance training session"],"participants":55,"study_design":"RANDOMIZED · FACTORIAL · PREVENTION · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Acute change in muscle size (cross sectional area, cm2) — Change from baseline at 5 minutes after a training session","Change in muscle size (cross sectional area, cm2) — Change from baseline to week 12","Acute change in muscle function (N) — Change from baseline at 5 minutes after a training session","Change in muscle function (N) — Change from baseline to week 12","Change in patellar tendon stiffness (N/mm) — Change from baseline to week 12","Acute change in patellar tendon stiffness (N/mm) — Change from baseline at 5 minutes after a training session","Change in muscle mass (kg) — Change from baseline to week 12","Change in bone mass (g) — Change from baseline to week 12","Acute change in muscle excitation (mV) — Change from baseline at 5 minutes after a training session","Change in muscle excitation (mV) — Change from baseline to week 12","Change in physical function — Change from baseline to week 12","Blood analysis: Acute change in oxidative stress — Change from baseline at 5 minutes after a training session","Blood analysis: Change in oxidative stress — Change from baseline to week 12","Blood analysis: Acute change in Inflammation — Change from baseline at 5 minutes after a training session (Acute)","Blood analysis: Change in inflammation — Change from baseline to week 12","Blood analysis: Acute change in anabolic processes — Change from baseline at 5 minutes after a training session","Blood analysis: Change in anabolic processes — Change from baseline to week 12","Blood analysis: Acute change in catabolic processes — Change from baseline at 5 minutes after a training session","Blood analysis: Change in catabolic processes — Change from baseline to week 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Source terminology contains: resistance training.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36450","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}