{"type":"trials","record":{"id":36587,"source_id":"clinicaltrials-gov","external_id":"NCT03849417","title":"Brain Imaging Biomarkers of Pathological Brain Aging in Late-life Depression","brief_summary":"This study investigates the relationships and differences in PET-MRI brain imaging biomarkers of abnormal aging and behavioral measures in late life depression compared to healthy controls, and evaluates relationships and differences in the same imaging and behavioral measures following electroconvulsive therapy. The study tests the hypotheses that late-life depression will be associated with higher levels of accelerated aging and brain disease biomarkers, and that electroconvulsive therapy works by stimulating the reorganization of brain tissue.The data collected with contribute to improved knowledge about the neurobiology of late-life psychopathology and its treatment.","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Universitaire Ziekenhuizen KU Leuven","enrollment":128,"countries":["Belgium"],"start_date":"2019-06-19","completion_date":"2024-12-01","last_update_date":"2024-06-25","source_url":"https://clinicaltrials.gov/study/NCT03849417","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:26.090953+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":null,"organization":"Universitaire Ziekenhuizen KU Leuven","interventions":["ECT"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Relationship between synaptic density and hippocampal volume in LLD — 1 day","Relationship between tau and hippocampal volume in LLD — 1 day","Relationship between tau and white matter (wm) pathology in LLD — 1 day","Effect of tau on medial temporal neural responses to emotional stimuli and functional connectivity in LLD — 1 day","Relationship between medial temporal pathology and stress — 1 week","Relationship between hippocampal volume increase following ECT and changes in synaptic density and tau — 8 weeks","Amyloid changes following ECT — 8 weeks"],"design_description":null,"source_has_results":false},"controlled_terms":["Depression","ECT"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: brain aging.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct03849417","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-06-19 to 2024-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.906Z","intervention":["ECT"],"participants":128,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Relationship between synaptic density and hippocampal volume in LLD — 1 day","Relationship between tau and hippocampal volume in LLD — 1 day","Relationship between tau and white matter (wm) pathology in LLD — 1 day","Effect of tau on medial temporal neural responses to emotional stimuli and functional connectivity in LLD — 1 day","Relationship between medial temporal pathology and stress — 1 week","Relationship between hippocampal volume increase following ECT and changes in synaptic density and tau — 8 weeks","Amyloid changes following ECT — 8 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: brain aging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36587","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}