{"type":"trials","record":{"id":36611,"source_id":"clinicaltrials-gov","external_id":"NCT04276610","title":"Words on the Brain: Can Reading Rehabilitation for Age-Related Vision Impairment Improve Cognitive Functioning?","brief_summary":"Age-related vision impairment and dementia both become more prevalent with increasing age. Research into the mechanisms of these conditions has proposed that some of their causes (e.g., macular degeneration/glaucoma and Alzheimer's disease) could be symptoms of an underlying common cause, or may be equally linked to a multifactorial context in frailty and aging. Research into sensory-cognitive aging has provided preliminary data that sensory decline may be linked to the progression of dementia through the concept of sensory deprivation. Preliminary data in hearing loss rehabilitation support the idea that improved hearing may have a beneficial effect on cognitive functioning; however, there are to date no data available to examine whether low vision rehabilitation, specifically for reading, could have an equally protective or beneficial effect on cognitive health. The present proposal aims to fill this gap.","overall_status":"Terminated","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Université de Montréal","enrollment":38,"countries":["Canada"],"start_date":"2017-05-16","completion_date":"2023-03-28","last_update_date":"2023-04-03","source_url":"https://clinicaltrials.gov/study/NCT04276610","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:26.090953+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"WOTB","age_range":"65 Years","comparator":"Healthy Control Participants","organization":"Université de Montréal","interventions":["Low Vision Reading Rehabilitation"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Rey Auditory Verbal Learning Test (RAVLT) — 15 minutes","Letter Number Sequencing task — 2 minutes","Montreal Cognitive Assessment - full or blind version — 4 minutes","1-n-back task — 3 minutes","Minnesota Reading Test (MNRead) — 2 minutes","Depression, Anxiety and Stress Scale — 5 minutes","Canadian Digit Triplet Test — 4 minutes","Magnetic Resonance Imaging (MRI) - for subset of participants — 45 minutes"],"design_description":"NON RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Age-related Macular Degeneration","Dementia","Low Vision","Low Vision Aids","Hearing Loss","Reading Problem","Cognitive Impairment","Low Vision Reading Rehabilitation"],"relevance_confidence":70,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct04276610","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-05-16 to 2023-03-28","comparator":"Healthy Control Participants","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.928Z","intervention":["Low Vision Reading Rehabilitation"],"participants":38,"study_design":"NON RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Rey Auditory Verbal Learning Test (RAVLT) — 15 minutes","Letter Number Sequencing task — 2 minutes","Montreal Cognitive Assessment - full or blind version — 4 minutes","1-n-back task — 3 minutes","Minnesota Reading Test (MNRead) — 2 minutes","Depression, Anxiety and Stress Scale — 5 minutes","Canadian Digit Triplet Test — 4 minutes","Magnetic Resonance Imaging (MRI) - for subset of participants — 45 minutes"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","title context","study type"],"relevance_score":70,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/36611","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}